S-Mg2(dobpdc): a metal–organic framework for determining chirality in amino acids

Hui Min Tay; Aditya Rawal; Carol Hua

doi:10.1039/D0CC05539E

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S-Mg₂(dobpdc): a metal–organic framework for determining chirality in amino acids†

Hui Min Tay,

^a Aditya Rawal^b and Carol Hua

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia
E-mail: carol.hua@unimelb.edu.au

^b Mark Wainwright Analytical Centre, University of New South Wales, Kensington, New South Wales, Australia

Abstract

Chirality is a key aspect of amino acids and is essential for life. Here, a chiral metal–organic framework, S-Mg₂dobpdc, is used to determine the chirality of three BOC protected amino acids (alanine, valine and proline) by ¹³C solid-state NMR with chemical shift differences of up to 1.3 ppm observed between enantiomers. The chiral sensitivity persists upon in situ deprotection of the amino acids by thermolysis of the BOC group.

This article is part of the themed collection: Functional Coordination Networks

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Article information

DOI: https://doi.org/10.1039/D0CC05539E
Article type: Communication
Submitted: 14 Aug 2020
Accepted: 30 Oct 2020
First published: 02 Nov 2020

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Chem. Commun., 2020,56, 14829-14832

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S-Mg₂(dobpdc): a metal–organic framework for determining chirality in amino acids

H. M. Tay, A. Rawal and C. Hua, Chem. Commun., 2020, 56, 14829 DOI: 10.1039/D0CC05539E

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