Candida albicans steryl 6-O-acyl-α-D-mannosides agonize signalling through Mincle

Tram Nguyen; Yuki Hosono; Takashi Shimizu; Sho Yamasaki; Spencer J. Williams

doi:10.1039/D0CC06263D

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Candida albicans steryl 6-O-acyl-α-d-mannosides agonize signalling through Mincle†

Tram Nguyen,‡^a Yuki Hosono,‡^bc Takashi Shimizu,^bc Sho Yamasaki

^bc and Spencer J. Williams

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia
E-mail: sjwill@unimelb.edu.au

^b Department of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan

^c Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita 565-0871, Japan

Abstract

The C-type lectin receptor Mincle binds Candida albicans and has been implicated in its pathobiology, but the molecular effectors responsible have not been identified. We report the synthesis of cholesteryl and ergosteryl 6-O-acyl-α-D-mannosides, produced by C. albicans mycelium, and demonstrate their ability to signal through human and mouse Mincle.

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Article information

DOI: https://doi.org/10.1039/D0CC06263D
Article type: Communication
Submitted: 16 Sep 2020
Accepted: 05 Nov 2020
First published: 05 Nov 2020

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Chem. Commun., 2020,56, 15060-15063

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Candida albicans steryl 6-O-acyl-α-D-mannosides agonize signalling through Mincle

T. Nguyen, Y. Hosono, T. Shimizu, S. Yamasaki and S. J. Williams, Chem. Commun., 2020, 56, 15060 DOI: 10.1039/D0CC06263D

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Chemical Communications

Candida albicans steryl 6-O-acyl-α-d-mannosides agonize signalling through Mincle†

Abstract

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Candida albicans steryl 6-O-acyl-α-D-mannosides agonize signalling through Mincle

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