Iron-promoted dealkylative carbene aminocyclization of δ-arylamino-α-diazoesters†
Daniel
Solé, 
*a
Israel
Fernández
*b
*a
Israel
Fernández
*b
Abstract
Herein, we report a novel methodology to access N-aryl proline derivatives using amino-tethered α-diazoesters and cheap, readily available iron salts. Mechanistically, the aminocyclization reaction involves the initial formation of an iron-carbene complex followed by a nucleophilic attack of the aniline nitrogen atom to give an ammonium ylide intermediate, which finally undergoes the iron-promoted dealkylation.
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