Issue 11, 2020
From the journal:

Chemical Science

A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide†

Taleah M. Levesque,a   R. Garrison Kinneya  and  Bruce A. Arndtsen ORCID logo *a  

* Corresponding authors

a Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 0B8, Canada
E-mail: bruce.arndtsen@mcgill.ca

Abstract

We describe the development of a new palladium-catalyzed method to generate ketones via the oxidative coupling of two arenes and CO. This transformation is catalyzed by simple palladium salts, and is postulated to proceed via the conversion of arenes into high energy aroyl triflate electrophiles. Exploiting the latter can also allow the synthesis of unsymmetrical ketones from two different arenes.

Graphical abstract: A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide

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Article information

DOI
https://doi.org/10.1039/D0SC00085J
Article type
Edge Article
Submitted
06 Jan 2020
Accepted
19 Feb 2020
First published
20 Feb 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2020,11, 3104-3109

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A palladium-catalyzed C–H functionalization route to ketones via the oxidative coupling of arenes with carbon monoxide

T. M. Levesque, R. G. Kinney and B. A. Arndtsen, Chem. Sci., 2020, 11, 3104 DOI: 10.1039/D0SC00085J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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