Asymmetric synthesis of cyclic β-amino carbonyl derivatives by a formal [3 + 2] photocycloaddition†
Miguel A.
Valle-Amores, 
a
Ana M.
Martínez-Gualda,
a
Leyre
Marzo,
a
Alberto
Fraile
*ab
and
José
Aleman
*ab
a
Ana M.
Martínez-Gualda,
a
Leyre
Marzo,
a
Alberto
Fraile
*ab
and
José
Aleman
*ab
Abstract
Herein, a visible-light mediated strategy unlocking a family of cyclic β-amino carbonyl derivatives bearing three contiguous stereogenic centres is introduced. The overall reactivity relies on the performance of the substrate-catalyst complex to assist both the enantiocontrol and the photoredox tasks. This transformation led to an enantioselective [3 + 2] photocycloaddition between coordinated α,β-unsaturated acyl imidazoles and cyclopropylamine derivatives.
![Graphical abstract: Asymmetric synthesis of cyclic β-amino carbonyl derivatives by a formal [3 + 2] photocycloaddition](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D1CC05867C&imageInfo.ImageIdentifier.Year=2022)
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