Issue 5, 2022
From the journal:

Chemical Communications

A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy†

Nicolás M. Casellas,‡ab   Gaole Dai, ORCID logo ‡c   Evelyn Y. Xue, ORCID logo c   Alba Fonseca,a   Dennis K. P. Ng, ORCID logo *c   Miguel García-Iglesias ORCID logo *abd  and  Tomás Torres ORCID logo *ab  

* Corresponding authors

a Department of Organic Chemistry and Institute for Advanced Research in Chemical Sciences (IadChem), Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente, 7, Madrid 28049, Spain
E-mail: tomas.torres@uam.es

b IMDEA Nanociencia, c/Faraday 9, Cantoblanco, Madrid 28049, Spain

c Department of Chemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China
E-mail: dkpn@cuhk.edu.hk

d QUIPRE Department, University of Cantabria, Avd. de Los Castros, 46, Santander 39005, Spain
E-mail: giglesiasm@unican.es

Abstract

A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. These nanoparticles can be taken up readily by cancer cells and localised predominately in lysosomes where they disassemble gradually, leading to activation in fluorescence emission and, photocytotoxicity, showing IC50 values of as low as 1.2 μM.

Graphical abstract: A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/D1CC05977G
Article type
Communication
Submitted
23 Oct 2021
Accepted
07 Dec 2021
First published
07 Dec 2021

Chem. Commun., 2022,58, 669-672

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A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy

N. M. Casellas, G. Dai, E. Y. Xue, A. Fonseca, D. K. P. Ng, M. García-Iglesias and T. Torres, Chem. Commun., 2022, 58, 669 DOI: 10.1039/D1CC05977G

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