Issue 24, 2021
From the journal:

Nanoscale Advances

Quantifying the effect of PEG architecture on nanoparticle ligand availability using DNA-PAINT†

Teodora Andrian, ORCID logo a   Silvia Pujals*a  and  Lorenzo Albertazzi ORCID logo *ab  

* Corresponding authors

a Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Baldiri Reixac 15-21, 08028 Barcelona, Spain
E-mail: l.albertazzi@tue.nl, lalbertazzi@ibecbarcelona.eu, spujals@ibecbarcelona.eu

b Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, 5612AZ Eindhoven, The Netherlands

Abstract

The importance of PEG architecture on nanoparticle (NP) functionality is known but still difficult to investigate, especially at a single particle level. Here, we apply DNA Point Accumulation for Imaging in Nanoscale Topography (DNA-PAINT), a super-resolution microscopy (SRM) technique, to study the surface functionality in poly(lactide-co-glycolide)–poly(ethylene glycol) (PLGA–PEG) NPs with different PEG structures. We demonstrated how the length of the PEG spacer can influence the accessibility of surface chemical functionality, highlighting the importance of SRM techniques to support the rational design of functionalized NPs.

Graphical abstract: Quantifying the effect of PEG architecture on nanoparticle ligand availability using DNA-PAINT

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Article information

DOI
https://doi.org/10.1039/D1NA00696G
Article type
Communication
Submitted
20 Sep 2021
Accepted
01 Nov 2021
First published
01 Nov 2021
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2021,3, 6876-6881

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Quantifying the effect of PEG architecture on nanoparticle ligand availability using DNA-PAINT

T. Andrian, S. Pujals and L. Albertazzi, Nanoscale Adv., 2021, 3, 6876 DOI: 10.1039/D1NA00696G

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