Issue 7, 2023
From the journal:

Chemical Communications

Endogenous G-quadruplex-forming RNAs inhibit the activity of SARS-CoV-2 RNA polymerase†

Tamaki Endoh, ORCID logo a   Shuntaro Takahashi ORCID logo a  and  Naoki Sugimoto ORCID logo *ab  

* Corresponding authors

a Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Kobe, Japan
E-mail: sugimoto@konan-u.ac.jp
Fax: +81-78-303-1495
Tel: +81-78-303-1147

b Graduate School of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Kobe, Japan

Abstract

Replication of RNA viruses is catalysed by virus-specific polymerases, which can be targets of therapeutic strategies. In this study, we used a selection strategy to identify endogenous RNAs from a transcriptome library derived from lung cells that interact with the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. Some of the selected RNAs weakened the activity of RdRp by forming G-quadruplexes. These results suggest that certain endogenous RNAs, which potentially form G-quadruplexes, can reduce the replication of viral RNAs.

Graphical abstract: Endogenous G-quadruplex-forming RNAs inhibit the activity of SARS-CoV-2 RNA polymerase

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Article information

DOI
https://doi.org/10.1039/D2CC05858H
Article type
Communication
Submitted
28 Oct 2022
Accepted
15 Dec 2022
First published
16 Dec 2022

Chem. Commun., 2023,59, 872-875

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Endogenous G-quadruplex-forming RNAs inhibit the activity of SARS-CoV-2 RNA polymerase

T. Endoh, S. Takahashi and N. Sugimoto, Chem. Commun., 2023, 59, 872 DOI: 10.1039/D2CC05858H

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