Issue 17, 2022
From the journal:

Chemical Society Reviews

Platinum nanoplatforms: classic catalysts claiming a prominent role in cancer therapy

Jose I. Garcia-Peiro,abc   Javier Bonet-Aleta, ORCID logo abc   Jesus Santamaria*abc  and  Jose L. Hueso ORCID logo *abc  

* Corresponding authors

a Instituto de Nanociencia y Materiales de Aragon (INMA) CSIC-Universidad de Zaragoza, Campus Rio Ebro, Edificio I + D, C/Poeta Mariano Esquillor, s/n, Zaragoza, Spain
E-mail: jlhueso@unizar.es, jesus.santamaria@unizar.es

b Department of Chemical and Environmental Engineering, University of Zaragoza, Spain, Campus Rio Ebro, C/ María de Luna, 3, 50018 Zaragoza, Spain

c Networking Res. Center in Biomaterials, Bioengineering and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029, Madrid, Spain

Abstract

Platinum nanoparticles (Pt NPs) have a well-established role as a classic heterogeneous catalyst. Also, Pt has traditionally been employed as a component of organometallic drug formulations for chemotherapy. However, a new role in cancer therapy is emerging thanks to its outstanding catalytic properties, enabling novel approaches that are surveyed in this review. Herein, we critically discuss results already obtained and attempt to ascertain future perspectives for Pt NPs as catalysts able to modify key processes taking place in the tumour microenvironment (TME). In addition, we explore relevant parameters affecting the cytotoxicity, biodistribution and clearance of Pt nanosystems. We also analyze pros and cons in terms of biocompatibility and potential synergies that emerge from combining the catalytic capabilities of Pt with other agents such as co-catalysts, external energy sources (near-infrared light, X-ray, electric currents) and conventional therapies.

Graphical abstract: Platinum nanoplatforms: classic catalysts claiming a prominent role in cancer therapy

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Article information

DOI
https://doi.org/10.1039/D2CS00518B
Article type
Review Article
Submitted
21 Jun 2022
First published
19 Aug 2022

Chem. Soc. Rev., 2022,51, 7662-7681

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Platinum nanoplatforms: classic catalysts claiming a prominent role in cancer therapy

J. I. Garcia-Peiro, J. Bonet-Aleta, J. Santamaria and J. L. Hueso, Chem. Soc. Rev., 2022, 51, 7662 DOI: 10.1039/D2CS00518B

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