The rates of Cu(II)–ATCUN complex formation. Why so slow?

Radosław Kotuniak; Paulina Szczerba; Dobromiła Sudzik; Marc J. F. Strampraad; Peter-Leon Hagedoorn; Wojciech Bal

doi:10.1039/D2DT02856E

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The rates of Cu(ii)–ATCUN complex formation. Why so slow?†

Radosław Kotuniak,^a Paulina Szczerba,^a Dobromiła Sudzik,^a Marc J. F. Strampraad,^b Peter-Leon Hagedoorn

^b and Wojciech Bal

*^a

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* Corresponding authors

^a Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warszawa, Poland
E-mail: wbal@ibb.waw.pl

^b Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands

Abstract

We used a series of modified/substituted GGH analogues to investigate the kinetics of Cu(II) binding to ACTUN peptides. Rules for rate modulation by 1^st and 2^nd sphere interactions were established, providing crucial insight into elucidation of the reaction mechanism and its contribution to biological copper transport.

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Article information

DOI: https://doi.org/10.1039/D2DT02856E
Article type: Communication
Submitted: 31 Aug 2022
Accepted: 14 Nov 2022
First published: 15 Nov 2022

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Dalton Trans., 2022,51, 17553-17557

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The rates of Cu(II)–ATCUN complex formation. Why so slow?

R. Kotuniak, P. Szczerba, D. Sudzik, M. J. F. Strampraad, P. Hagedoorn and W. Bal, Dalton Trans., 2022, 51, 17553 DOI: 10.1039/D2DT02856E

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The rates of Cu(ii)–ATCUN complex formation. Why so slow?†

Abstract

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The rates of Cu(II)–ATCUN complex formation. Why so slow?

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