SCHEDULED MAINTENANCE
Efficient access to β-amino acid ester/β-amino ketone derivatives via photocatalytic radical alkoxycabonylimidation/carbonylimidation of alkenes†
Peng-Ju
Xia, 
*a
Ying-Ming
Pan,
a
*a
Ying-Ming
Pan,
a
Abstract
A photocatalytic protocol for the synthesis of β-amino acid ester and β-amino ketone derivatives is developed using simple and easy-to-synthesize oxime oxalate and oxime phenylglyoxylate as difunctionalization reagents. These bifunctional reagents were used to generate iminyl and alkoxycarbonyl/benzoyl radicals via energy transfer-promoted N–O bond homolysis and decarbonation. More than 40 highly functionalized β-amino acid ester and β-amino ketone derivatives were obtained in 60–86% yields by taking advantage of different kinds of olefins such as ordinary aromatics, α-trifluoromethylstyrenes and β-CF3-1,3-enynes.
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