Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units

Carlos R. Arza; Xiaoya Li; Sedef İlk; Yang Liu; Deniz Demircan; Baozhong Zhang

doi:10.1039/D2TB01233B

Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units†

Carlos R. Arza,‡^a Xiaoya Li,

‡^a Sedef İlk,

^b Yang Liu,^c Deniz Demircan^a and Baozhong Zhang

*^a

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* Corresponding authors

^a Centre for Analysis and Synthesis, Department of Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden
E-mail: baozhong.zhang@chem.lu.se

^b Niğde Ömer Halisdemir University, Faculty of Medicine, Department of Immunology, TR-51240 Niğde, Turkey

^c Faculty of Medicine, Department of Clinical Sciences, Orthopedics, Lund University, Lund, Sweden

Abstract

This work aimed to develop biocompatible non-leachable antimicrobial polymers without ionic structures. A series of nonionic hyperbranched polymers (HBPs) with an isatin-based backbone and phenolic terminal units were synthesized and characterized. The molecular structures and thermal properties of the obtained HBPs were characterized by SEC, NMR, FTIR, TGA and DSC analyses. Disk diffusion assay revealed significant antibacterial activity of the obtained phenolic HBPs against nine different pathogenic bacteria. The presence of a methoxy or long alkyl group close to the phenolic unit enhanced the antibacterial effect against certain Gram positive and negative bacteria. The obtained nonionic HBPs were blended in polyester poly(hexamethylene terephthalate) films, which showed no noticeable leakage after being immersed in water for 5 days. Finally, these HBPs showed no cytotoxicity effect to MG-63 osteoblast-like human cells according to MTT analysis, and negligible hemolytic effect.

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DOI: https://doi.org/10.1039/D2TB01233B
Article type: Paper
Submitted: 14 Jun 2022
Accepted: 08 Sep 2022
First published: 09 Sep 2022
This article is Open Access

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J. Mater. Chem. B, 2022,10, 8064-8074

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Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units

C. R. Arza, X. Li, S. İlk, Y. Liu, D. Demircan and B. Zhang, J. Mater. Chem. B, 2022, 10, 8064 DOI: 10.1039/D2TB01233B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Journal of Materials Chemistry B

Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units†

Abstract

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Biocompatible non-leachable antimicrobial polymers with a nonionic hyperbranched backbone and phenolic terminal units

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