Synthetic approaches to the naphthyl-isoquinoline alkaloids. Part 1. Dehydroancistrocladisine
Abstract
A synthesis of (±)-7-(4,5-dimethoxy-2-methyl-1-naphthyl)-6,8-dimethoxy-1,3-dimethylisoquinoline (dehydroancistrocladisine)19, the racemic form of a degradation product of the unusual naphthylisoquinoline alkaloid ancistrocladisine 3, is recorded. The key step relied on oxazoline chemistry for the construction of the biaryl linkage.