Current reviewXenotransplantation: Past achievements and future promise
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Cited by (11)
Chapter 16 - Biology and Diseases of Swine
2015, Laboratory Animal Medicine: Third EditionXenotransplantation: Where are we in 2008?
2008, Kidney InternationalCitation Excerpt :Removal of anti-αGal antibodies and depletion or inhibition of complement in nonhuman primate recipients were found to protect pig xenografts from HAR but not from AHXR, which is mediated by returning anti-αGal or newly elicited anti-non-αGal xenoreactive antibodies.23 Transgenic pigs were developed expressing human complement regulatory proteins, for example, hDAF (human decay-accelerating factor, CD55),6 MCP (membrane cofactor protein, CD46),7 or protectin (CD59),8 but although grafts from these donor pigs were protected from HAR, they are not completely protected from AHXR.24 Using a combination of CD46 transgene pig heart grafts, the α-galactosyl-polyethylene glycol conjugate TPC, and conventional immunosuppression in baboons, McGregor et al.25,26 have obtained a median heart graft survival time of 75–90 days.
FK778 in Experimental Xenotransplantation: A Detailed Analysis of Drug Efficacy
2007, Journal of Heart and Lung TransplantationA new cardiac concordant xenotransplantation model
2005, Transplantation Proceedings