Clinical–alimentary tractTime Trends of Ulcer Mortality in Europe
Section snippets
Data Sources
Initially, mortality data from 16 different European countries were analyzed. The present analysis was restricted to 6 exemplary countries listed in Table 1. Three countries were chosen because their vital statistics regarding peptic ulcer covered a time period of more than 70 years (Denmark, The Netherlands, and Switzerland). Three other countries (France, Germany, and Spain) were chosen because of their large population size and large number of ulcer cases. Data from other European countries
Results
Figure 1 shows the period-age contours of mortality from gastric ulcer among the 6 countries. In general, mortality is much higher among the older than among the younger age groups. With the exception of Switzerland, the same line patterns in different countries refer to the same age groups. To present the time trends of all age groups in a single graph, a logarithmic y-axis is chosen. In all countries alike, the period-age contours of gastric ulcer mortality appear to be arranged in a fan-like
Discussion
The present study analyzed the birth-cohort patterns of mortality from gastric and duodenal ulcers in 6 exemplary European countries. The first aim of the study was to assess the ubiquity and similarity of the birth-cohort patterns among different countries. The second aim was to determine the latest trends of ulcer disease and assess the influence of the most recent data on the overall pattern. The analysis reveals that a birth-cohort pattern has continued to influence the temporal variations
References (30)
- et al.
20 years of hospital admissions for peptic ulcer in England and Wales
Lancet
(1981) - et al.
Rising frequency of ulcer perforation in elderly people in the United Kingdom
Lancet
(1986) - et al.
The long-term time trends of ulcerative colitis and peptic ulcer are interrelated
Am J Gastroenterol
(2002) - et al.
Helicobacter pylori: recombination, population structure and human migrations
Int J Med Microbiol
(2004) Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model
Gastroenterology
(1997)- et al.
Surgical treatment of peptic ulcer in the United StatesTrends before and after the introduction of cimetidine
Lancet
(1981) Peptic ulcer
Mount Sinai J Med
(2000)Perforated peptic ulcerChanges in age-incidence and sex-distribution in the last 150 years
Lancet
(1940)Disability pensions due to peptic ulcer in Germany between 1953 and 1983
Am J Epidemiol
(1985)- et al.
Time trends in peptic ulcer surgery, 1956 to 1986A nation-wide survey in Sweden
Ann Surg
(1989)
Civilization and peptic ulcer
Lancet
Temporal trends and geographic variations of peptic ulcer disease
Aliment Pharmacol Ther
Causes underlying the birth-cohort phenomenon of peptic ulcer: analysis of mortality data 1911–2000, England and Wales
Int J Epidemiol
Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects
Gut
Period effects, generation effects and age effects in peptic ulcer mortality
J Chron Dis
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2019, American Journal of MedicineCitation Excerpt :Peptic ulcer disease has also been found to be associated with increasing age.8 Over time, a significant decrease in peptic ulcer disease diagnoses, as well as its associated complications, has been observed in both the United States and elsewhere in the world.9-12 The majority of peptic ulcer disease cases are now known to be associated with H. pylori infection or the use of nonsteroidal antiinflammatory drugs (NSAIDs), or both.13
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