Regular ArticleThe effect of 24 months recombinant human growth hormone (rh-GH) on LDL cholesterol, triglyceride-rich lipoproteins and apo [a] in hypopituitary adults previously treated with conventional replacement therapy
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Decreased TNF-α gene expression in periodontal ligature in MSG-obese rats: A possible protective effect of hypothalamic obesity against periodontal disease?
2012, Archives of Oral BiologyCitation Excerpt :The ARC is responsible for the synthesis of the growth hormone-releasing hormone (GHRH), thus the plasma GH concentration is reduced in MSG-obese rodents.17,18 This hormone has lipolytic activity,28 therefore the accumulation of fat and reduction of the naso-anal length can be partly attributed to the reduction in GH. The plasma concentration of total CHOL was similar between the studied groups, but the neonatal MSG treatment caused an increase in TG and NEFA concentrations in comparison with CTL.
Impact of 5 years of growth hormone replacement therapy on cardiovascular risk factors in growth hormone-deficient adults
2008, Metabolism: Clinical and ExperimentalCitation Excerpt :Results are also variable regarding other lipid measurements: HDL-C levels have increased after GH therapy in some studies [12,14,23,47] but not in others [14,16,26,48,49], whereas mean serum TG concentration was reduced [14,50] or unchanged [12,16,23,26,48,49,51] after GH treatment. Lastly, Lp(a) levels increased in most studies [49-51] but not in all [54-56]. The highly atherogenic apo B, the principal protein component of LDL-C, has so far only been under-investigated in GHD patients receiving GH substitution, as well as apo A-1 levels, the major constituent of HDL-C.
Management of growth hormone deficiency in adults
2007, Growth Hormone and IGF ResearchGrowth hormone replacement throughout life: Insights into age-related responses to treatment
2007, Growth Hormone and IGF ResearchCarotid artery intima-media thickness and lipid profile in adults with growth hormone deficiency after long-term growth hormone replacement
2005, Metabolism: Clinical and Experimental