Clinical studyMultiple sclerosis in Australia: prognostic factors
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Long-term MS secondary progression: Derivation and validation of a clinical risk score
2020, Clinical Neurology and NeurosurgeryCitation Excerpt :Pure motor symptoms or motor symptoms associated with cerebellar symptoms were also associated with long-term moderate-to-severe disability [29]. The frequency of patients with secondary progression was 49 % for polysymptomatic relapses versus 75 % for pyramidal relapses and 72 % for cerebellar relapses [29]. The risk of secondary progression in patients with initial involvement of the pyramidal type was 2.5 versus 3.1 for sphincter involvement, 1.5 for cerebellar involvement, and 1.8 for polysymptomatic presentation [28].
Rehabilitation in Multiple Sclerosis: A Systematic Review of Systematic Reviews
2017, Archives of Physical Medicine and RehabilitationPrognostic factors associated with long-term disability and secondary progression in patients with Multiple Sclerosis
2016, Multiple Sclerosis and Related DisordersCitation Excerpt :In addition, the risk of reaching EDSS 6 has been reported to be 1.5-fold greater (Debouverie, 2009). In other studies, univariate analysis showed that the median time from the onset of the disease until reaching the established EDSS markers was significantly lower in men (Damasceno et al., 2013; Debouverie, 2009; Cree et al., 2004; Hammond et al., 2000; Debouverie et al., 2007). Furthermore, the time until secondary progression was shorter in males (Scalfari et al., 2013; Koch et al., 2010).
Flexible modeling of disease activity measures improved prognosis of disability progression in relapsing-remitting multiple sclerosis
2015, Journal of Clinical EpidemiologyCitation Excerpt :Initially, relapsing–remitting form of MS, male gender, older age at onset, cerebellar and sphincter involvement at onset, and incomplete recovery after the first MS attack are all associated with worse disease course [39–41]. In addition, two measures of early disease activity (1) the number of attacks in the first 2 years after diagnosis and (2) the length of the interval between the first two MS attacks were also suggested to be useful prognostic factors [40,42], but their actual impact remains controversial [40,42,43], and it is unclear which has higher prognostic utility [8]. Some discrepancies in results can be partly explained by between-studies differences in: patient populations (unselected vs. specialized reference centers) [44], inclusion of patients with different forms of MS [40,45], definitions of the beginning of follow-up [46], choice of the specific level of disability as the end point, and follow-up duration [47,48].
Beneficial effects of vitamin D on neurodegeneration and mental diseases
2014, Cahiers de Nutrition et de DietetiqueSeason of birth as a risk factor for multiple sclerosis in Brazil
2013, Journal of the Neurological SciencesCitation Excerpt :The risk factors for the onset of MS have not yet been fully defined. Degree of latitude [6–16], season of birth [2,3,17–24], vitamin D deficiency [25–27] and childhood infections [3,23,28–30] are the most studied environmental factors that may be associated with this disease. Several international studies have suggested that a springtime birth would substantially increase the risk of an individual developing MS at some point in the future.