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Planta Med 2011; 77(8): 773-785
DOI: 10.1055/s-0030-1270924
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© Georg Thieme Verlag KG Stuttgart · New York

Natural Inhibitors of Pancreatic Lipase as New Players in Obesity Treatment

Ana Laura de la Garza1 , Fermín I. Milagro1 , Noemí Boque1 , Javier Campión1 , J. Alfredo Martínez1
  • 1Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
Further Information

Publication History

received Dec. 7, 2010 revised February 11, 2011

accepted February 21, 2011

Publication Date:
16 March 2011 (online)

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Abstract

Obesity is a multifactorial disease characterized by an excessive weight for height due to an enlarged fat deposition such as adipose tissue, which is attributed to a higher calorie intake than the energy expenditure. The key strategy to combat obesity is to prevent chronic positive impairments in the energy equation. However, it is often difficult to maintain energy balance, because many available foods are high-energy yielding, which is usually accompanied by low levels of physical activity.

The pharmaceutical industry has invested many efforts in producing antiobesity drugs; but only a lipid digestion inhibitor obtained from an actinobacterium is currently approved and authorized in Europe for obesity treatment. This compound inhibits the activity of pancreatic lipase, which is one of the enzymes involved in fat digestion.

In a similar way, hundreds of extracts are currently being isolated from plants, fungi, algae, or bacteria and screened for their potential inhibition of pancreatic lipase activity. Among them, extracts isolated from common foodstuffs such as tea, soybean, ginseng, yerba mate, peanut, apple, or grapevine have been reported. Some of them are polyphenols and saponins with an inhibitory effect on pancreatic lipase activity, which could be applied in the management of the obesity epidemic.

Key words

Orlistat - high fat diet - polyphenols - saponins - obesity - fat digestion

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Prof. J. Alfredo Martinez

Department of Nutrition and Food Sciences, Physiology and Toxicology
University of Navarra

c/Irunlarrea 1

31008 Pamplona

Spain

Phone: +34 9 48 42 56 00

Fax: +34 9 48 42 56 49

Email: jalfmtz@unav.es

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