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Planta Med 2012; 78(4): 390-392
DOI: 10.1055/s-0031-1298175
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Isolation and Cytotoxic Activity of Selaginellin Derivatives and Biflavonoids from Selaginella tamariscina

Guo-gang Zhang1 , Ying Jing1 , Hong-mei Zhang1 , En-long Ma2 , Jin Guan3 , Feng-ning Xue1 , Hong-xia Liu1 , Xiao-ya Sun1
  • 1College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China
  • 2School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, P. R. China
  • 3College of Applied Chemistry, Shenyang Institute of Chemical Technology, Shenyang, P. R. China
Further Information

Publication History

received November 5, 2011 revised December 9, 2011

accepted December 16, 2011

Publication Date:
23 January 2012 (online)

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Abstract

Five selaginellin derivatives, including two new selaginellins termed selaginellins M (1) and N (2), and three previously identified compounds, selaginellin (3), selaginellin A (4), and selaginellin C (5), were isolated from the Selaginella tamariscina (Beauv.) Spring plant. In addition, four known biflavonoids, namely neocryptomerin (6), hinokiflavone (7), pulvinatabiflavone (8), and 7′′-O-methylamentoflavone (9), were also isolated. The structures of new compounds 1 and 2 were elucidated by spectroscopic analysis. The cytotoxic activity of compounds 1-9 was evaluated against a small panel of human cancer cell lines, including U251 (human glioma cells), HeLa (human cervical carcinoma cells), and MCF-7 (human breast cancer cells). The two new selaginellins, selaginellins M (1) and N (2), showed medium activity against the human cancer cell lines.

Key words

Selaginella tamariscina - Selaginellaceae - selaginellin - biflavonoid - cytotoxic activity

Supporting Information

References

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Prof. Guo-Gang Zhang

College of Traditional Chinese Materia Medica
Shenyang Pharmaceutical University

No. 103 Wenhua Road

Shenyang 110016

People's Republic of China

Phone: +86 24 23 98 65 11

Fax: +86 24 23 98 65 11

Email: Zhangguogang821@hotmail.com

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