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Synthesis 2013; 45(5): 596-600
DOI: 10.1055/s-0032-1318116
DOI: 10.1055/s-0032-1318116
paper
A Formal Synthesis of (±)-Cephalotaxine via Pauson–Khand Reaction
Further Information
Publication History
Received: 14 November 2012
Accepted after revision: 27 December 2012
Publication Date:
31 January 2013 (online)
Abstract
A concise route toward the formal synthesis of (±)-cephalotaxine has been developed. An intermolecular Pauson–Khand reaction was adopted to construct the cyclopentenone ring efficiently with high regioselectivity.
Key words
(±)-cephalotaxine - alkaloids - intermolecular Pauson–Khand reaction - cycloaddition - cyclopentenones - regioselectivitySupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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For reviews on the Cephalotaxus alkaloids, see:
For some examples, see: