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Synlett 1993; 1993(10): 774-776
DOI: 10.1055/s-1993-22605
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The Horner-Wadsworth-Emmons Reaction in Natural Products Synthesis: Expedient Construction of Complex (E)-Enones Using Barium Hydroxide

Ian Paterson* , Kap-Sun Yeung, Jeff B. Smaill
  • *University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, England
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Publication History

Publication Date:
19 March 2002 (online)

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The barium hydroxide promoted Horner-Wadsworth-Emmons reaction is a mild and efficient method for the coupling of ß-ketophosphonates with structurally complex, base-sensitive aldehydes in equimolar quantities to give (E)-enones.

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