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Planta Med 2001; 67(2): 176-179
DOI: 10.1055/s-2001-11505
Letter

© Georg Thieme Verlag Stuttgart · New York

Piperine Inhibits Gastric Emptying and Gastrointestinal Transit in Rats and Mice

Sunil Bajad1 , K. L. Bedi1,*, A. K. Singla2 , R. K. Johri1
  • 1 Pharmacology Division, Regional Research Laboratory (CSIR), Jammu, India
  • 2 Department of Pharmaceutics, UIPS, Panjab University, Chandigarh, India
Further Information

Publication History

February 29, 2000

July 2, 2000

Publication Date:
31 December 2001 (online)

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Abstract

Piperine (1), an alkaloid of black and long peppers, inhibited gastric emptying (GE) of solids/liquids in rats and gastrointestinal transit (GT) in mice in a dose and time dependent manner. Compound 1 significantly inhibited GE of solids and GT at the doses extrapolated from humans (1 mg/kg and 1.3 mg/kg p.o. in rats and mice, respectively). However, at the same dose the effect was insignificant for GE of liquids. One week oral treatment of 1 mg/kg and 1.3 mg/kg in rats and mice, respectively, did not produce a significant change in activity as compared to single dose administration. GE inhibitory activity of 1 is independent of gastric acid and pepsin secretion.

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Dr. K. L. Bedi

Chairman

Pharmacology Division

Regional Research Laboratory

Canal Road

Jammu 180 001

India

Email: rrlj@nde.vsnl.net.in or sbajad@yahoo.com

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