Recent Advances in Solution-Phase Multicomponent Methodology for the Synthesis of Heterocyclic Compounds

 

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Abstract

Following the increased interest from the pharmaceutical industry for the generation of diverse libraries of heterocyclic compounds, scientific efforts have become more and more focused on the development of novel multi-component procedures as a means of gaining rapid access to such compounds. Initially, the development of solid-phase procedures received considerable attention. However, current efforts are increasingly concerned with the development of solution-phase procedures. The latter will be the subject of discussion in this review, which aims to give an overview of the progress made in the past decade.

After a general introduction, non-catalyzed, acid-catalyzed, and transition metal-catalyzed solution-phase multi-component procedures for the preparation of a wide range of heterocycles will be discussed. The last chapter discusses the role of cycloaddition reactions in the development of novel MCRs for the synthesis of heterocyclic compounds.

In spite of their important role in the synthesis of heterocyclic compounds, MCRs involving isocyanides are not discussed in this review, since the topic has been exhaustively reviewed several times.

• 1Introduction

• 2Non-Catalyzed MCRs

• 3Acid-Catalyzed MCRs

• 4Transition Metal-Catalyzed or -Mediated MCRs

• 5MCRs Involving Cycloaddition Reactions

• 6Conclusions and Outlook

References

• 1 Nicolaou KC. Vourloumis D. Winssinger N. Baran PS. Angew. Chem. Int. Ed.  2000,  39:  24 ; Angew. Chem. 2000, 112: 46
  Google Scholar
• 2 Wender PA. Handy ST. Wright DL. Chem. Ind. (London)  1997,  765 
  Google Scholar
• 3 Hall N. Science  1994,  266:  32 
  CrossrefGoogle Scholar
• 4a Passerini M. Gazz. Chim. Ital.  1921,  51:  121 
  CrossrefGoogle Scholar
• 4b Passerini M. Gazz. Chim. Ital.  1921,  51:  181 
  CrossrefGoogle Scholar
• 4c Ugi C. inventors; Steinbrückner DE-B  1,103,337. 
  Crossref
• 4d Ugi C. Chem. Ber.  1961,  94:  734 
  CrossrefGoogle Scholar
• 4e Ugi I. Dömling A. Hörl W. Endeavour  1994,  18:  115 
  CrossrefGoogle Scholar
• 5 For example see: Tietze LF. Chem. Rev.  1996,  96:  115 
  CrossrefPubMedGoogle Scholar
• 6 Denmark SE. Thorarensen A. Chem. Rev.  1996,  96:  137 
  CrossrefPubMedGoogle Scholar
• 7 Dömling A. Ugi I. Angew. Chem. Int. Ed.  2000,  39:  3168 ; Angew. Chem. 2000, 112, 3300
  CrossrefPubMedGoogle Scholar
• 8 Bienaymé H. Hulme CH. Oddon G. Schmitt P. Chem.-Eur. J.  2000,  6:  3321 
  Google Scholar
• 9 For example see: Bravo PA. Carrero MCP. Galan ER. Blazquez JAS. Heterocycles  2000,  1:  81 
  Google Scholar
• 10 For example see: Neuschutz K. Velker J. Neier R. Synthesis  1998,  3:  227 
  Article in Thieme ConnectGoogle Scholar
• 11 For example see: Organ MG. Winkle DD. Huffman J. J. Org. Chem.  1997,  62:  5254 
  CrossrefGoogle Scholar
• 12 For example see: Johnson WS. Gravestock MB. McCarry BE. J. Am. Chem. Soc.  1971,  93:  4332 
  CrossrefGoogle Scholar
• 13 Ranu BC. Hajra A. Tetrahedron  2001,  57:  4767 
  CrossrefGoogle Scholar
• 14 Weber L. Illgen K. Almstetter M. Synlett  1999,  366 
  Article in Thieme ConnectGoogle Scholar
• 15 Kitano Y. Chiba M. Tada M. Tetrahedron Lett.  1998,  39:  1911 
  Google Scholar
• 16 Strecker S. Liebigs Ann. Chem.  1850,  27 
  Google Scholar
• 17 Cotterill IC. Usyatinsky AY. Arnold JM. Clark DS. Dordick JS. Michels PC. Khmelnitsky YL. Tetrahedron Lett.  1998,  39:  1117 
  CrossrefGoogle Scholar
• 18 Hantzsch A. Ber. Dtsch. Chem. Ges.  1890,  23:  1474 
  CrossrefGoogle Scholar
• 19a Biginelli P. Ber. Dtsch. Chem. Ges.  1891,  24:  1317 
  Google Scholar
• 19b Kappe CO. Acc. Chem. Res.  2000,  33:  879 
  Google Scholar
• 19c Kappe CO. Eur. J. Med. Chem.  2000,  35:  1043 
  Google Scholar
• 19d Dondoni A. Massi A. Sabbatini S. Tetrahedron Lett.  2002,  43:  5913 
  Google Scholar
• 20 Robinson RJ. Chem. Soc.  1917,  762 
  Google Scholar
• 21 Arend M. Westermann B. Risch N. Angew. Chem. Int. Ed.  1998,  37:  1044 ; Angew. Chem. 1998, 110, 1096
  CrossrefPubMedGoogle Scholar
• 22 List B. Synlett  2001,  1675 
  Article in Thieme ConnectGoogle Scholar
• 23a Bergs H. inventors; DE-B  566,094. 
  Crossref
• 23b Bucherer T. Barsch H. J. Prakt. Chem.  1934,  140:  151 
  CrossrefGoogle Scholar
• 23c Alonso F. Micó I. Nájera C. Sansano JM. Yus M. Ezquerra J. Yruretagoyena B. Gracia I. Tetrahedron  1995,  51:  10259 
  CrossrefGoogle Scholar
• 24a Asinger F. Angew. Chem.  1958,  71:  67 
  CrossrefGoogle Scholar
• 24b Dömling A. Ugi I. Tetrahedron  1993,  49:  9495 
  CrossrefGoogle Scholar
• 25 Dömling A. Bayler A. Ugi I. Tetrahedron  1995,  51:  755 
  CrossrefGoogle Scholar
• 26 Schlemminger I. Janknecht HH. Maison W. Saak W. Martens J. Tetrahedron Lett.  2000,  41:  7289 
  Google Scholar
• 27 Bossio R. Marcos CF. Maracaccini S. Pepino R. Tetrahedron Lett.  1997,  38:  2519 
  CrossrefGoogle Scholar
• 28 Zhang JD. Jacobson A. Rusche JR. Herlihy W. J. Org. Chem.  1999,  64:  1074 
  CrossrefGoogle Scholar
• 29 Maracaccini S. Torroba T. Org. Prep. Proced. Int.  1993,  25:  141 
  CrossrefGoogle Scholar
• 30 Kobayashi S. Chem. Soc. Rev.  1999,  28:  1 
  CrossrefGoogle Scholar
• 31 Dax SL. McNally JJ. Youngman MA. Curr. Med. Chem.  1999,  6:  255 
  PubMedGoogle Scholar
• 32 Sim MM. Ganesan A. J. Org. Chem.  1997,  62:  3230 
  CrossrefGoogle Scholar
• 33 Gewald K. Chem. Ber.  1965,  98:  3571 
  Google Scholar
• 34 McKibben BP. Cartwright CH. Castelhano AL. Tetrahedron Lett.  1999,  40:  5471 
  CrossrefGoogle Scholar
• 35 Pinto IL. Jarvest RL. Serafinowska HT. Tetrahedron Lett.  2000,  41:  1597 
  CrossrefGoogle Scholar
• 36 Rajasekharan KN. Nair KP. Jenardanan GC. Synthesis  1986,  353 
  Article in Thieme ConnectGoogle Scholar
• 37 Hantzsch AR. Weber JH. Ber. Dtsch. Chem. Ges.  1887,  20:  3118 
  CrossrefGoogle Scholar
• 38 Masquelin TH. Obrecht D. Tetrahedron  2001,  57:  153 
  CrossrefGoogle Scholar
• 39 Singh SP. Parmar SS. Raman K. Stenberg VI. Chem. Rev.  1981,  81:  175 
  CrossrefGoogle Scholar
• 40 De Vries AHM. Hof RP. Staal D. Kellog RM. Feringa BL. Tetrahedron: Asymmetry  1997,  8:  1539 
  CrossrefGoogle Scholar
• 41 Strijtveen BM. Kellog RM. J. Org. Chem.  1986,  51:  3664 
  Google Scholar
• 42 Holmes CP. Chinn JP. Look GC. Gordon EM. Gallop MA. J. Org. Chem.  1995,  60:  7328 
  Google Scholar
• 43 Ware E. Chem. Rev.  1950,  46:  403 
  CrossrefGoogle Scholar
• 44 Hanessian S. Yang RY. Tetrahedron Lett.  1996,  37:  5835 
  CrossrefGoogle Scholar
• 45 Katritzky AR. Fali CN. Li J. J. Org. Chem.  1997,  62:  4148 
  Google Scholar
• 46 Langer P. Döring M. Görls H. Eur. J. Org. Chem.  2001,  1511 
  Google Scholar
• 47 Beckert R. Mayer R. Wiss. Z. Techn. Universität Dresden  1987,  2:  36 
  Google Scholar
• 48 Naik SN. Pandey B. Ayyanger NR. Synth. Commun.  1988,  18:  625 
  Google Scholar
• 49a Zupancic JJ. Horn KA. Schuster GB. J. Am. Chem. Soc.  1980,  102:  5279 
  CrossrefGoogle Scholar
• 49b Greene FD. J. Am. Chem. Soc.  1956,  78:  2250 
  CrossrefGoogle Scholar
• 50 Petasis NA. Akritopoulou I. Tetrahedron Lett.  1993,  34:  583 
  CrossrefGoogle Scholar
• 51 Petasis NA. Goodman A. Zavialov IA. Tetrahedron  1997,  53:  16463 
  CrossrefGoogle Scholar
• 52 Petasis NA. Zavialov IA. J. Am. Chem. Soc.  1998,  120:  11798 
  CrossrefGoogle Scholar
• 53 Petasis NA. Boral S. Tetrahedron Lett.  2001,  42:  539 
  CrossrefGoogle Scholar
• 54 Berrée F. Debache A. Marsac Y. Carboni B. Tetrahedron Lett.  2001,  42:  3591 
  CrossrefGoogle Scholar
• 55 Varma RS. Green Chem.  1999,  1:  43 
  CrossrefGoogle Scholar
• 56 Quiroga J. Cisneros C. Insuasty B. Abonía R. Nogueras M. Sánchez A. Tetrahedron Lett.  2001,  42:  5625 
  CrossrefGoogle Scholar
• 57 Lee HK. Chui WK. Bioorg. Med. Chem.  1999,  7:  1255 
  CrossrefGoogle Scholar
• 58 Modest EJ. J. Org. Chem.  1956,  21:  1 
  Google Scholar
• 59 Suginome M. Ohmori Y. Ito Y. Chem. Commun.  2001,  1090 
  Google Scholar
• 60 Billet M. Klotz PH. Mann A. Tetrahedron Lett.  2001,  42:  631 
  Google Scholar
• 61 For example see: Ishihara K. Funahashi M. Hanaki N. Miyata M. Yamamoto H. Synlett  1994,  963 
  Article in Thieme ConnectGoogle Scholar
• 62 Kobayashi S. Synlett  1994,  689 
  Article in Thieme ConnectGoogle Scholar
• 63 Kobayashi S. Hachiya I. J. Org. Chem.  1994,  59:  3590 
  Google Scholar
• 64 Kobayashi S. Hachiya I. Takahori T. Araki M. Ishitani H. Tetrahedron Lett.  1992,  33:  6815 
  CrossrefGoogle Scholar
• 65 Hachiya I. Kobayashi S. J. Org. Chem.  1993,  58:  6958 
  Google Scholar
• 66 Narasaka K. Tanaka H. Kanai F. Bull. Chem. Soc. Jpn.  1991,  64:  387 
  Google Scholar
• 67 Kawada A. Mitamura S. Kobayashi S. Chem. Commun.  1993,  1157 
  Google Scholar
• 68 Hachiya I. Kobayashi S. Tetrahedron Lett.  1994,  35:  3319 
  CrossrefGoogle Scholar
• 69 Kobayashi S. Hachiya I. Ishitana H. Araki M. Tetrahedron Lett.  1993,  34:  4535 
  CrossrefGoogle Scholar
• 70 Kobayashi S. Ishitani H. Nagayama S. Synthesis  1995,  1195 
  Article in Thieme ConnectGoogle Scholar
• 71 For example see: Martens J. Scheunemann M. Tetrahedron Lett.  1991,  32:  1417 
  Google Scholar
• 72 For example see: Aggarwal VK. Thompson A. Jones RVH. Standen MCH. J. Org. Chem.  1996,  61:  8368 
  CrossrefGoogle Scholar
• 73 Nagayama S. Kobayashi S. Chem. Lett.  1998,  6852 
  Google Scholar
• 74 Kubo T. Sakaguchi S. Ishii Y. Chem.Commun.  2000,  625 
  Google Scholar
• 75 Annunziata R. Cinquini M. Cozzi F. Molteni V. Schupp O. J. Org. Chem.  1996,  61:  8293 
  Google Scholar
• 76 Okitsu O. Oyamada H. Furuta T. Kobayashi S. Heterocycles  2000,  52:  1143 
  CrossrefGoogle Scholar
• 77 Palomo C. Aizpurua JM. Gracenea JJ. García-Granda S. Pertierra P. Eur. J. Org. Chem.  1998,  2201 
  CrossrefGoogle Scholar
• 78 Annunziata R. Cinquini M. Cozzi F. Molteni V. Schupp O. Tetrahedron  1996,  52:  2573 
  CrossrefGoogle Scholar
• 79a Hirai K. Iwano Y. Mikoshiba I. Koyama H. Nishi T. Heterocycles  1994,  38:  277 
  Google Scholar
• 79b Hirai K. Homma H. Mikoshiba I. Heterocycles  1994,  38:  281 
  Google Scholar
• 80 Oyamada H. Kobayashi S. Synlett  1998,  249 
  Article in Thieme ConnectGoogle Scholar
• 81 Kobayashi S. Hamada T. Manabe K. Synlett  2001,  1140 
  Article in Thieme ConnectGoogle Scholar
• 82 Kobayashi S. Akiyama R. Moriwaki M. Tetrahedron Lett.  1997,  38:  4819 
  CrossrefGoogle Scholar
• 83 Blackburn CH. Guan B. Fleming P. Shiosaki K. Tsai S. Tetrahedron Lett.  1998,  39:  3635 
  CrossrefGoogle Scholar
• 84 Kobayashi S. Akiyama R. Moriwaki M. Tetrahedron Lett.  1997,  38:  4819 
  CrossrefGoogle Scholar
• 85 Kobayashi S. Tamura M. Mukaiyama T. Chem. Lett.  1988,  91 
  Google Scholar
• 86 Shiraishi H. Kawasaki Y. Sakaguchi S. Nishiyama Y. Ishii Y. Tetrahedron Lett.  1996,  37:  7291 
  Google Scholar
• 87 Shiraishi H. Nishitani T. Sakaguchi S. Ishii Y. J. Org. Chem.  1998,  63:  6234 
  CrossrefGoogle Scholar
• 88 Nishitani T. Shiraishi H. Sakaguchi S. Ishii Y. Tetrahedron Lett.  2000,  41:  3389 
  CrossrefGoogle Scholar
• 89a McKillop A. Young DW. Synthesis  1979,  401 
  Article in Thieme ConnectGoogle Scholar
• 89b McKillop A. Young DW. Synthesis  1979,  481 
  Article in Thieme ConnectGoogle Scholar
• 90 Varma RS. Kumar D. Tetrahedron Lett.  1999,  40:  7665 
  CrossrefGoogle Scholar
• 91a Balalaie S. Arabanian A. Green Chem.  2000,  2:  274 
  Google Scholar
• 91b Usyatinsky AY. Khmelnitsky YL. Tetrahedron Lett.  2000,  41:  5031 
  Google Scholar
• 92 Ranu BC. Hajra A. Jana U. Synlett  2000,  75 
  Article in Thieme ConnectGoogle Scholar
• 93 Stoeck V. Schunack W. Arch. Pharmaz.  1974,  307:  922 
  Google Scholar
• 94a Stoeck V. Schunack W. Arch. Pharm.  1976,  309:  421 
  CrossrefGoogle Scholar
• 94b Lipshutz BH. Morey MC. J. Org. Chem.  1983,  48:  3745 
  CrossrefGoogle Scholar
• 94c Peddibhotla S. Jayakumar S. Tepe JJ. Org. Lett.  2002,  4:  3533 
  CrossrefGoogle Scholar
• 95a Schubert H. Stodolka H. J. Prakt. Chem.  1963,  22:  130 
  Google Scholar
• 95b Krieg B. Manecke G. Z. Naturforsch., B: Chem. Sci.  1967,  22:  132 
  Google Scholar
• 95c Dghaym RD. Dhawan R. Arndtsen BA. Angew. Chem. Int. Ed.  2002,  40:  3228 
  Google Scholar
• 96a Varma RS. Dahiya R. J. Org. Chem.  1998,  63:  8038 
  CrossrefGoogle Scholar
• 96b Varma RS. Tetrahedron  2002,  58:  1235 
  CrossrefGoogle Scholar
• 97 Sonogashira K. Metal-catalyzed Cross-coupling Reactions   Diederich F. Stang PJ. Wiley-VCH; Weinheim: 1998.  p.203 
  Google Scholar
• 98 Müller TJJ. Ansorge M. Aktah D. Angew. Chem. Int. Ed.  2000,  39:  1323;   Angew. Chem. 2000, 112, 1323
  CrossrefGoogle Scholar
• 99 Müller TJJ. Braun R. Ansorge M. Org. Lett.  2000,  2:  1967 
  CrossrefGoogle Scholar
• 100 Braun RU. Zeitler K. Müller TJJ. Org. Lett.  2000,  2:  4181 
  CrossrefGoogle Scholar
• 101 Chaplin JH. Flynn BL. Chem. Commun.  2001,  1594 
  CrossrefGoogle Scholar
• 102 Flynn BL. Verdier-Pinard P. Hamel E. Org. Lett.  2001,  3:  651 
  CrossrefPubMedGoogle Scholar
• 103 Braun RU. Zeitler K. Müller TJJ. Org. Lett.  2001,  3:  3297 
  CrossrefGoogle Scholar
• 104 Arcadi A. Cacchi S. Fabrizi G. Moro L. Eur. J. Org. Chem.  1999,  1137 
  CrossrefGoogle Scholar
• 105 Boykin DW. Kumar A. Bajic M. Xiao G. Wilson WD. Bender BC. McCurdy DR. Hall JE. Tidwell RR. Eur. J. Med. Chem.  1997,  32:  965 
  Google Scholar
• 106 Balme G. Bouyssi D. Faure R. Gore J. Van Hemelryck B. Tetrahedron  1992,  48:  3891 
  CrossrefGoogle Scholar
• 107 Cavicchioli M. Sixdenier E. Derrey A. Bouyssi D. Balme G. Tetrahedron Lett.  1997,  38:  1763 
  Google Scholar
• 108a Bottex M. Cavicchioli M. Hartmann B. Monteiro N. Balme G. J. Org. Chem.  2001,  66:  175 
  CrossrefGoogle Scholar
• 108b Azoulay S. Monteiro N. Balme G. Tetrahedron Lett.  2002,  43:  9311 
  CrossrefGoogle Scholar
• 108c Clique B. Vassiliou S. Monteiro N. Balme G. Eur. J. Org. Chem.  2002,  1493 
  CrossrefGoogle Scholar
• 109 Clique B. Monteiro N. Balme G. Tetrahedron Lett.  1999,  40:  1301 
  Google Scholar
• 110 Hayes JF. Shipman M. Twin H. Chem. Commun.  2000,  1791 
  Google Scholar
• 111a Hayes JF. Shipman M. Twin H. Chem. Commun.  2001,  1784 
  Google Scholar
• 111b Hayes JF. Shipman M. Twin H. J. Org. Chem.  2002,  67:  935 
  Google Scholar
• 112 Kobayashi S. Ishitani H. Nagayama S. Chem. Lett.  1995,  423 
  Google Scholar
• 113 Ali T. Chauhan KK. Frost ChG. Tetrahedron Lett.  1999,  40:  5621 
  CrossrefGoogle Scholar
• 114a Akiyama T. Takaya J. Kagoshima H. Tetrahedron Lett.  1999,  40:  7831 
  CrossrefGoogle Scholar
• 114b Akiyama T. Matsuda K. Fuchibe K. Synlett  2002,  1898 
  CrossrefGoogle Scholar
• 114c Yuan Y. Li X. Ding K. Org. Lett.  2002,  4:  3309 
  CrossrefGoogle Scholar
• 115a Annunziata R. Cinquini M. Cozzi F. Molteni V. Schupp O. Tetrahedron  1997,  53:  9715 
  CrossrefGoogle Scholar
• 115b Annunziata R. Benaglia M. Ciquini M. Cozzi F. Eur. J. Org. Chem.  2002,  1184 
  CrossrefGoogle Scholar
• 116a Schmidt RR. Angew. Chem., Int. Ed. Engl.  1973,  12:  212 
  CrossrefGoogle Scholar
• 116b Shono T. Matsumura Y. Inoue K. Ohmizu H. Kashimura S. J. Am. Chem. Soc.  1982,  104:  5753 
  CrossrefGoogle Scholar
• 117 Kobayashi S. Nagayama S. J. Am. Chem. Soc.  1996,  118:  8977 
  CrossrefGoogle Scholar
• 118 Baudelle R. Melnyk P. Déprez B. Tartar A. Tetrahedron  1998,  54:  4125 
  CrossrefGoogle Scholar
• 119 Sartori G. Bigi F. Maggi R. Mazzacani A. Oppici G. Eur. J. Org. Chem.  2001,  2513 
  Google Scholar
• 120 Batey RA. Simoncic PD. Lin D. Smyj RP. Lough AJ. Chem. Commun.  1999,  651 
  Google Scholar
• 121a Batey RA. Powell DA. Chem. Commun.  2001,  2362 
  CrossrefGoogle Scholar
• 121b Powell DA. Batey RA. Org. Lett.  2002,  4:  2913 
  CrossrefGoogle Scholar
• 122 Wamhoff H. Schmidt A. J. Org. Chem.  1993,  58:  6976 
  Google Scholar
• 123 Wamhoff H. Bamberg CH. Herrmann S. Nieger M. J. Org. Chem.  1994,  59:  3985 
  CrossrefGoogle Scholar
• 124 Cravotto G. Nano GM. Palmisano G. Pilati T. Tagliapietra S. J. Heterocycl. Chem.  2001,  38:  965 
  Google Scholar
• 125 Appendino G. Cravotto G. Minassi A. Palmisano G. Eur. J. Org. Chem.  2001,  3711 
  CrossrefGoogle Scholar
• 126 Nair V. Vinod AU. Chem. Commun.  2000,  1019 
  CrossrefGoogle Scholar
• 127 Nair V. Vinod AU. Nair JS. Sreekanth AR. Rath NP. Tetrahedron Lett.  2000,  41:  6675 
  CrossrefGoogle Scholar
• 128a Nair V. Vinod AU. Rajesh C. J. Org. Chem.  2001,  66:  4427 
  CrossrefGoogle Scholar
• 128b Nair V. Sreekanth AR. Abhilash N. Bhadbhade MM. Gonnade RC. Org. Lett.  2002,  4:  3575 
  CrossrefGoogle Scholar
• 129 Kobayashi S. Akiyama R. Kawamura M. Ishitani H. Chem. Lett.  1997,  1039 
  CrossrefGoogle Scholar
• 130 McKiernan MT. Heaney F. Tetrahedron Lett.  1996,  37:  4597 
  CrossrefGoogle Scholar
• 131 Righi P. Marotta E. Rosini G. Chem.-Eur. J.  1998,  4:  2501 
  Google Scholar
• 132 Avalos M. Babiano R. Cintas P. Jiménez JL. Palacios JC. Silva MA. Chem.Commun.  1998,  459 
  Google Scholar
• 133 Avalos M. Babiano R. Cintas P. Higes FJ. Jiménez JL. Palacios JC. Silva MA. J. Org. Chem.  1999,  64:  1494 
  CrossrefGoogle Scholar
• 134 Fokas D. Ryan WJ. Casebier DS. Coffen DL. Tetrahedron Lett.  1998,  39:  2235 
  CrossrefGoogle Scholar
• 135 Nair V. Sheela KC. Rath NP. Eigendorf GK. Tetrahedron Lett.  2000,  41:  6217 
  CrossrefGoogle Scholar
• 136a Ardil H. Grigg R. Shridharan V. Surendrakumar S. Thianpatanagul S. Kanajun S. Chem. Commun.  1986,  602 
  CrossrefGoogle Scholar
• 136b Blaney P. Grigg R. Rankovic Z. Thornton-Pett M. Xu J. Tetrahedron  2002,  58:  1719 
  CrossrefGoogle Scholar
• 136c Grigg R. Koppen I. Rasparini M. Sridharan V. Chem. Commun.  2001,  964 
  CrossrefGoogle Scholar
• 136d Casaschi A. Grigg R. Sansano JM. Tetrahedron  2001,  57:  607 
  CrossrefGoogle Scholar