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Planta Med 2004; 70(9): 874-877
DOI: 10.1055/s-2004-827240
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Activity of Compounds from the Lichen: Cladonia convoluta

Carine Bézivin1 , Sophie Tomasi1 , Isabelle Rouaud1 , Jean-Guy Delcros2 , Joël Boustie1
  • 1Institut de Chimie de Rennes. Laboratoire de Pharmacognosie et de Mycologie. UPRES 2234 ”Synthèse et extraction de molécules à visée thérapeutique”, Rennes, France
  • 2Groupe de recherche en thérapeutique anticancéreuse, Faculté de Médecine, Rennes, France
Further Information

Publication History

Received: February 25, 2004

Accepted: June 13, 2004

Publication Date:
23 September 2004 (online)

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Abstract

The depsidone 9′-(O-methyl)protocetraric acid was isolated from the lichen Cladonia convoluta (Lam.) Anders along with the known (-)-usnic acid and fumarprotocetraric acid. The complete structure of 9′-(O-methyl)protocetraric acid was elucidated using HSQC and HMBC spectral data. (-)-Usnic acid was the only compound to display a moderate cytotoxic activity on various cancer cell lines (IC50 = 6, 12.1, 15.8, 17.8, 8.2 and 6.8 μg/mL on L1210, 3LL, DU145, MCF7, K-562 and U251, respectively). This compound was also shown to induce apoptosis of murine leukaemia L1210 cells in a dose- and time-dependent manner.

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S. Tomasi

Faculté de Pharmacie

Laboratoire de Pharmacognosie et de Mycologie

2 Avenue du Professeur Léon Bernard

35043 Rennes Cedex

France

Phone: +33-223-234-817

Fax: +33-223-234-704

Email: sophie.tomasi@univ-rennes1.fr

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