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Planta Med 1993; 59(5): 418-420
DOI: 10.1055/s-2006-959722
Paper

© Georg Thieme Verlag Stuttgart · New York

Perfusion with Picroliv Reverses Biochemical Changes Induced in Livers of Rats Toxicated with Galactosamine or Thioacetamide1

Yogesh Dwivedi2 , Ravi Rastogi2 , Narendra Kumar Garg2 , Bhola Nath Dhawan2
  • 2ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow - 226 001, India
1 CDRI communication No. 5049
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Publication History

1992

1993

Publication Date:
04 January 2007 (online)

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Abstract

Perfusion of liver of rats toxicated with galactosamine or thioacetamide with a 0.02% solution of picroliv (glycoside fraction of Picrorhiza kurroa) for 30 min (1 ml/min; 6 mg/rat), significantly reversed toxicant-induced changes in the activities of several enzymes. Galactosamine induced increases in the activities of alkaline phosphatase, γ-glutamyl transpeptidase, acid ribonuclease, acid phosphatase, succinate dehydrogenase and decreases in the activities of Na+-K+-adenosine triphosphatase (ATPase) and glucose-6-phosphatase (reversed by 40-87%). Similarly, thioacetamide-induced inhibitions of the activities of Na+-K+-ATPase, Ca+ +-ATPase, Mg+ +-ATPase, succinate dehydrogenase and elevations in the activities of alkaline phosphatase, γ-glutamyl transpeptidase, and acid ribonuclease were also significantly reversed. A significant reversal of the toxicants-induced decrease in [14 C]-leucine incorporation was also observed. These results indicate that picroliv can also reverse D-galactosamine-or thioacetamide-induced hepatic damage in rats.

Key words

Galactosamine - thioacetamide - picroliv perfusion - hepatotoxicity - hepatic enzymes

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