Download PDF
Horm Metab Res 1993; 25(3): 156-159
DOI: 10.1055/s-2007-1002067
Originals Basic

© Georg Thieme Verlag, Stuttgart · New York

Effect of Ascorbic Acid Administration on B and E Apoproteins in Rats Fed a Cholesterol Enriched Diet

M. Santillo, F. Santangelo, A. Belfiore, M. Mastursi, P. Mondola
  • Institute of Human Physiology, Second Faculty of Medicine and Surgery, University of Naples, Naples, Italy
Further Information

Publication History

1992

1992

Publication Date:
14 March 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

The effect of ascorbic acid on cholesterol metabolism is very well documented; it is ascribed to the activation of this vitamin on cholesterol 7α-hydroxylase (EC 1.14) that activates the catabolism of cholesterol. In this paper we have studied the effect of the administration of ascorbic acid on B and E apoproteins of rats fed a diet anriched with 1.5% of cholesterol. The results obtained show that ascorbic acid is able to affect cholesterol metabolism by modifying the serum levels of apo B in total serum and in lipoprotein classes of density less than 1.050 g/ml. Moreover the ascorbic acid treatment reduced the amount of cholesterol and triglycerides in all lipoprotein classes examined. No significant change of total serum apo E was observed following ascorbic acid administration.

Key words

Ascorbic Acid - Cholesterol - apo B - apo E

      >