Development of Glucose Intolerance in Obese (fa/fa) Zucker Rats

R. Apweiler; P. Freund

doi:10.1055/s-2007-1002165

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Horm Metab Res 1993; 25(10): 521-524
DOI: 10.1055/s-2007-1002165

Originals Basic

Development of Glucose Intolerance in Obese (fa/fa) Zucker Rats

R. Apweiler¹ , P. Freund²

¹Zentrum für Molekulare Biologie Heidelberg, Heidelberg
²Boehringer Mannheim Germany, Department of Medical Research, Mannheim, Germany

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Publication History

1993

1993

Publication Date:
14 March 2008 (online)

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Summary

Development of glucose intolerance in genetically obese (fa/fa) rats was investigated. Comparisons were made with lean (FA/?) control rats. Oral glucose tolerance tests were performed in 7-8 weeks, 9-10 weeks, 12-13 weeks and 16-17 weeks old rats. Irrespectively of age, the obese rats showed impaired glucose tolerance and insulin sensitivity compared with age-matched lean rats. While in FA/? rats only minor changes of glucose-stimulated insulin secretion and glucose tolerance were observed with progression of age, glucose intolerance in obese animals became more pronounced with aging. Obese rats older than 12-13 weeks showed no further progression of glucose intolerance. Glucose-stimulated insulin secretion increased with aging, but basal insulinemia was unaffected. Hence, we conclude that glucose intolerance and insulin resistance in genetically obese (fa/fa) rats is almost completely developed with approximately 12 weeks.

Key words

Insulin Resistance - Obesity - Glucose Intolerance - OGTT - fa/fa Rats

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