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Synthesis 2010(2): 283-287  
DOI: 10.1055/s-0029-1217097
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed One-Pot Synthesis of 4-Aryl-1H-1,2,3-triazoles from anti-3-Aryl-2,3-dibromopropanoic Acids and Sodium Azide

Wensheng Zhanga,b, Chunxiang Kuang*a, Qing Yangc
a Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China
Fax: +86(21)65983191; e-Mail: kuangcx@tongji.edu.cn;
b Department of Chemistry, Jiaozuo Teachers’ College, Jiaozuo 454001, P. R. of China
c Department of Biochemistry, School of Life Sciences, Fudan University, Handan Road 220, Shanghai 200433, P. R. of China
Further Information

Publication History

Received 24 August 2009
Publication Date:
03 November 2009 (online)

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Abstract

4-Aryl-1H-1,2,3-triazoles were synthesized from anti-3-aryl-2,3-dibromopropanoic acids and sodium azide by a one-pot method using N,N-dimethylformamide as solvent in the presence of tris(dibenzylideneacetone)dipalladium(0) [Pd2(dba)3] and Xantphos.

Key words

1H-1,2,3-triazole - anti-3-aryl-2,3-dibromopropanoic acid - sodium azide - Pd2(dba)3 - one-pot

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