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An imagined future community: Taiwan Biobank, Taiwanese genome, and nation-building

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Abstract

Based on the concept of an imagined future community, this article analyzes the relationship between the establishment of a national biobank (Taiwan Biobank) and nation-building. This article examines (1) the shift in state policy from pursuing a Sci-Tech Island to an Island of Biomedical Technology for the purpose of strengthening the national economy and Taiwan’s global competitiveness in biomedicine, (2) the discourses about the uniqueness of the Taiwanese genome as a niche in the competitive global biomedical market, and (3) scientists’ imaginary of the necessity of a national genetic project for the health of Taiwan’s future generations. By exploring how the discourse of the Taiwanese genome as a niche has been constructed, this article reveals that life science and scientists’ imaginary of the futurity who have played important roles in Taiwan’s nation-building. We argue that the future imaginaries contained in the scientific discourse regarding Taiwan Biobank reflect the ideas of global scientific competition, connections between genetic distinctness and nationality, and the health of future generations in Taiwan.

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Notes

  1. The proposed work included the following: (1) to convene a conference of Taiwanese scientists, physicians, and ethicists to set up a plan for establishing a population genetic database in Taiwan; (2) to establish a population genetic database in Taiwan, which includes permanent DNA samples from all Taiwanese who agree to participate; (3) to make the population genetic database available to qualified researchers to study (a) the effects of gene variants on Taiwanese health and well-being, (b) the effects of gene variants on medication response, and (c) the genetic relationship of Taiwanese with other population groups; (4) to educate the Taiwanese about the genetic contribution to health and well- being, and (5) to study ethical issues raised by a population genetic database and its impact on the Taiwanese (Tsuang 2000).

  2. Inspired by the literature, we use the term futurity instead of future to capture the interactions between past, present, and future. In other words, futurity does not just mean a particular moment in the future but also refers to dynamics and performativity that shapes the present in multiple ways. See more discussion in the Science, Imaginary, and Futurity section.

  3. Through the scientific method of prospective cohort study, TBB aims to record participants’ health, disease, and lifestyle information for the long term as part of the infrastructure for medical and pharmaceutical research that could benefit future generations of national population. See more discussion in the section on Taiwan must have its own lab.

  4. This bionationalistic support for Hwang was halted after Hwang's lab was embroiled in a scientific misconduct scandal in 2015. The scandal brought the Korean scientific community into worldwide discredit and also damaged the entire Korean biotechnology sector. In contrast to the previously unreserved support from the political and institutional realms, including public funding, loose legal and ethical governance, and the mobilization of female oocyte from the Korean society, this scandal shocked the political system, national self-esteem, and Korean identity (Gottweis and Kim 2010).

  5. There has also been growing literature on futurity in relation to technoscientific innovation in the past two decades, such as the sociology of expectations (Borup et al. 2006; Brown and Michael 2003), and studies about promise, anticipation or hope (Brown and Michael 2003; Hedgecoe and Martin 2003; Adams et al. 2009). Compared to the other future-oriented notions, the concept of imaginaries pays particular attention to how technoscientific futures are interconnected with political and cultural practices.

  6. We also interviewed social scientists who help establish the ethical and governance framework, and those who challenge the ELSI problems of TBB. However, scientists regarded the social scientists who critically debate on TBB as anti-science and irrational, resulting in the neglect of diverse values underlying public controversy, and in restrictions on innovative governance practices. In considering the main research questions and arguments of this article, we did not include the interviews with social scientists. More discussion can be seen in Lee and Tsai (2018).

  7. There were only a few subjects discussed in STAG relevant to biomedicine such as the prevention of Hepatitis B and biopharmaceutical industry.

  8. Lee participated the meetings of STAG in 1994, 1995, 1998, 1999, 2000, 2001, 2002, 2003, 2005, and 2007. The meeting was held annually with an exception of 2007. He was the head of STAG from 1999 to 2007 and Chi-Huey Wong was his successor, serving from 2008 to 2011. http://www.bost.ey.gov.tw/Content_List.aspx?n=F0558A90D837D63E (cited on October 28, 2015).

  9. “Sep 2015 J2” denotes that the interview with J2 in September 2015. See the interview list in the Appendix.

  10. In the SRB on biotechnology, 5 out of the 14 specialists who participated in the first SRB meeting in 1997 were Academicians of Academia Sinica.

  11. Please visit the official website of BOST. http://www.bost.ey.gov.tw/news.aspx?n=BBF2DDAD69A41B16&sms=E1CE7A91363ABB7D (cited on October 28, 2015).

  12. Stage 1: the pre-feasibility project (from September to December 2003); Stage 2: the feasibility project (from August 2005 to July 2007); Stage 3: the preparatory phase of the establishment of Taiwan Biobank (the pilot study project, December 2005 to October 2010); and Stage 4: the extension project of the pilot study (from December 2010 to December 2011).

  13. Before 1971, China’s representation by either the Republic of China and the Peoples Republic of China had been disputed in the UN. The UN once suggested that Chiang Kai-shek, the Kuomintang government (KMT) of the Republic of China, should change the name of the nation from China to Taiwan, which would allow the ROC using the name of Taiwan to stay in the UN. However, the KMT government refused to accept the concept of dual representation under a two Chinas option in the UN because it insisted on declaring itself the sole legitimate government of China. By contrast, the KMT government proposed that the UN should exclude the participation of Communist China. The Beijing government (the People’s Republic of China) took over the seat of Taiwan on the UN Security Council.

  14. iPSC stands for induced pluripotent stem cells.

  15. APOLLO stands for Applied Proteogenomics Organizational Learning and Outcomes.

  16. Now the project is named Cancer Breakthroughs 2020. For more detail see http://www.cancermoonshot2020.org/home/ (accessed 29 October 2016).

  17. Taiwanese subjectivity is based on a political and cultural discourse of Taiwan-centeredness through multiculturalism and Taiwanese nationalism to challenge Chinese nationalism and to establish the Taiwanese identity as an independent country.

  18. Tsai’s research (2014) also points out that the scientific research regarding the rediscovery of Taiwanese ancestry and the genetic attributes of the Taiwanese appeared since the late 1990s after the martial law ended. She argues that the scientific knowledge produced in the lab has spilled over into the Taiwanese society in general through conferences, journals, media, and the like since the 1990s and brought about significant social impacts as part of the phenomena of the ethnicization of biomedicine and the biomedicalization of ethnicity. Furthermore, Liu (2010) also explored the construction of Taiwanese identity based on aboriginal genetic research to illustrate how the production of scientific knowledge is taken up in identity making and nation-building.

  19. See the research conducted by the Election Study Center of National Chengchi University. (accessed on October 28, 2015).

  20. See the related discussion of Hsiau (2000) and Wang (2005) for more details.

  21. The new immigrants refers to a group of new residents who have either migrated to Taiwan or intermarried with local Taiwanese. Foreign brides means those who originated mainly from certain countries in Asia, such as China, Indonesia, Thailand, Vietnam, Thailand, and Philippines since the 1990s, which form the majority of new immigrants. From foreign brides to new immigrants, this illustrates social and political attempts to conceal the potential stigma inherent in the term foreign brides and to recognize them as part of Taiwan.

  22. To illustrate the promising nature of the Taiwanese population at the global level of bioeconomy, the example of Stevens-Johnson Syndrome (SJS) was often invoked. Yuan-Tsong Chen, the leading scientist of TBB, published an article, "Medical genetics: a marker for Stevens-Johnson syndrome" in Nature with his colleagues in 2004 (Chung et al. 2004). That article shows there is a strong association in Han Chinese between a genetic marker, HLA-B*1502, and SJS induced by carbamazepine, a drug commonly prescribed for the treatment of seizure disorders. The biological samples used in the research were collected in Taiwan, but the conclusion of that article refers to the Chinese population around the world. Accordingly, the FDA of the United States, based on the conclusion of this article, recommended genotyping all Asians before the prescription of carbamazepine, to avoid medical risk (Ferrell and Mcleod 2008). It constitutes distinct Han Chinese bodies or Asian bodies through Taiwanese ones and mobilizes the Taiwanese into both global and local domains as a good population and a valuable resource.

  23. We are not going to examine the human classification in biomedical research. However, many STS studies have pointed out that human classification, in terms of race, ethnicity, and nationality in science is not pure science but is deeply rooted in the social, cultural, and political context (Duster 2005; Epstein 2007; Fujimura et al. 2008; Goodman 2000). The human classification in biomedical research is always politically referential (Bliss 2012, p. 204).

  24. Taiwan Biobank, Latest News. http://www.twBiobank.org.tw/new_web/news.php?article_option=news&article_add= (accessed on October 26, 2015).

  25. Taiwan Biobank, Recruiting Videos: the Seeds and the Best https://www.youtube.com/watch?v=Xkg_hXJrlhk (accessed on October 26, 2015) (Taiwan Biobank 2013).

  26. Taiwan Biobank, Latest News, http://www.twBiobank.org.tw/new_web/news.php?article_option=news&article_add= (accessed on October 26, 2015).

  27. See the unpublished results of the participant satisfaction survey administered by TBB in September 2016.

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Acknowledgements

An earlier version of this paper was presented at The Society for Social Studies of Science (4S) annual conference (Australia, Sydney 2008). The authors sincerely thank Joel F. Stocker, Shun-Nan Chiang, Jia-Shin Chen, Sean Hsiang-Lin Lei, and three anonymous reviewers for their useful comments and suggestions. Yu-yueh Tsai would like to thank Professor Joan Fujimura (Department of Sociology, University of Wisconsin-Madison) for her inspiring guidance and encouragement. This research is part of the project funded by first author’s “Outstanding Young Scholar Research Project” from Taiwan’s National Science Council (NSC102-2628-H001-006-MY2).

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Appendix: The interview list

Appendix: The interview list

Interviewee

Background

Interview date

Scientist A

Genetics, Epidemiology

November 2012

October 2015

Scientist B

Biomedicine, Immunology

October 2015

August 2016

Scientist C

Genomic Medicine, Epidemiology

February 2011

October 2012

September 2015

August 2016

Scientist D

Genomic Medicine, Epidemiology

March 2011

Scientist E

Genomic Medicine, Immunology

September 2012

Scientist F

Genomic Medicine, Epidemiology

January 2013

Scientist G

Statistical Genetics, Epidemiology

October 2016

Scientist H

Biomedicine, Internal medicine

November 2016

Clinician H1

TBB Advisory Committee Member, Public Health, Epidemiology

December 2012

Clinician H2

TBB Advisory Committee Member, Public Health, Epidemiology

November 2012

Clinician H1

EGC member, Genetics

January 2011

Clinician H2

EGC member, Community Medicine Practitioner

March 2011

December 2012

Administrator J1

Former Ministry of Health, Hospital Director

January 2013

October 2015

Administrator J2

Former Official of the Ministry of Health, Researcher of National Research Program for Biopharmaceuticals

March 2011

September 2015

January 2016

November 2016

Administrator J3

Researcher of the Department of Technology and Development, the Ministry of Health

November 2016

Administrator J4

Former Official of the Biotechnology, Health, Medicine and Agriculture Division of the BOST, Executive Yuan

October 2016

Industry Representative K1

Industry Representative in TBB, Former Official of the Ministry of Economic Affairs, Microbiology

March 2011

September 2015

Industry Representative K2

Industry Representative in TBB. President of a Genomic Medicine

March 2011

October 2012

August 2016

Industry Representative K3

Principal Engineer of the TBB Information Platform, Former Researcher of the Institute for Information Industry

March 2011

July 2016

Public Participant R1

From Chaiyi

February 2016

Public Participant R2

From Chaiyi

February 2016

Public Participant R3

From HsinChu

October 2016

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Tsai, YY., Lee, WJ. An imagined future community: Taiwan Biobank, Taiwanese genome, and nation-building. BioSocieties 16, 88–115 (2021). https://doi.org/10.1057/s41292-019-00179-z

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