Preparation of the Central Tryptophan Moiety of the Celogentin/Moroidin Family of Anti-Mitotic Cyclic Peptides

Alexander K. L. Yuen; Katrina A. Jolliffe; Craig A. Hutton

doi:10.1071/CH06324

RESEARCH ARTICLE

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Preparation of the Central Tryptophan Moiety of the Celogentin/Moroidin Family of Anti-Mitotic Cyclic Peptides

Alexander K. L. Yuen ^A , Katrina A. Jolliffe ^A and Craig A. Hutton ^B ^C

+ Author Affiliations

- Author Affiliations

^A School of Chemistry, University of Sydney, Sydney NSW 2006, Australia.

^B School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne VIC 3010, Australia.

^C Corresponding author. Email: chutton@unimelb.edu.au

Australian Journal of Chemistry 59(11) 819-826 https://doi.org/10.1071/CH06324
Submitted: 1 September 2006 Accepted: 2 October 2006 Published: 17 November 2006

Abstract

The central functionalized tryptophan core of the celogentin/moroidin family of cyclic peptides has been prepared. The strategy incorporates a novel preparation of 4-iodobenzaldehyde and employs a Larock annulation as the key step.

Acknowledgment

This work was supported by the Australian Research Council (DP0208190).

References

Preparation of the Central Tryptophan Moiety of the Celogentin/Moroidin Family of Anti-Mitotic Cyclic Peptides

Abstract

Acknowledgment

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