Journal of Biological Chemistry
Molecular Bases of DiseaseUnusual zwitterionic catalytic site of SARS–CoV-2 main protease revealed by neutron crystallography
Cited by (0)
This article contains supporting information.
Author contributions—D. W. K., Q. Z., H. M. O., and L. C. formal analysis; D. W. K., K. L. W., S. P., Q. Z., and L. C. validation; D. W. K., G. P., K. L. W., S. P., and Q. Z. investigation; D. W. K. and L. C. visualization; D. W. K. and A. K. writing-original draft; G. P., K. L. W., S. P., and Q. Z. methodology; K. L. W., Q. Z., and H. M. O. resources; H. M. O. funding acquisition; H. M. O., L. C., and A. K. writing-review and editing; L. C. and A. K. conceptualization; L. C. data curation; A. K. supervision; A. K. project administration.
Funding and additional information—This work was supported by the Department of Energy Office of Science through the National Virtual Biotechnology Laboratory, a consortium of Department of Energy national laboratories focused on response to COVID-19, with funding provided by the Coronavirus CARES Act. This work used resources at the Spallation Neutron Source and the High Flux Isotope Reactor, which are Department of Energy Office of Science User Facilities operated by the Oak Ridge National Laboratory. The Office of Biological and Environmental Research supported research at the Oak Ridge National Laboratory Center for Structural Molecular Biology, a Department of Energy Office of Science user facility. This work also used resources at the Second Target Station, which is a Department of Energy Office of Science user facilities construction project at Oak Ridge National Laboratory.
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Abbreviations—The abbreviations used are:
- SARS
severe acute respiratory syndrome
- CoV-2
coronavirus 2
- PDB
Protein Data Bank.