Journal of Biological Chemistry
Volume 286, Issue 51, 23 December 2011, Pages 44035-44044
NeurobiologyDiacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model*
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open access
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Oxidative Stress
Superoxide Dismutase (SOD)
Transgenic Mice
CuII(atsm)
SODG93A
TDP-43
Peroxynitrite
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- *
This work was supported by the Australian National Health and Medical Research Council (NHMRC), C. J. Martin Fellowship 359269 (to B. J. T.), the Bethlehem Griffiths Research Foundation, the Motor Neurone Disease Research Institute of Australia, and the Australian Research Council.
The on-line version of this article (available at http://www.jbc.org) contains supplemental Tables S1 and S2 and Figs. S1–S3.
© 2011 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.