Journal of Biological Chemistry
Volume 290, Issue 34, 21 August 2015, Pages 20649-20659
Signal TransductionCrystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor*♦Crystal Structure of the GRK5·CCG215022 Complex
Under a Creative Commons license
open access
enzyme inhibitor
plasma membrane
protein kinase
site-directed mutagenesis
x-ray crystallography
G protein-coupled receptor kinase
crystallography
membrane targeting
rational drug design
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The atomic coordinates and structure factors (code 4WNK) have been deposited in the Protein Data Bank (http://wwpdb.org/).
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This work was supported, in whole or in part, by National Institutes of Health Grants HL071818 and HL086865 (to J. T.) and was conducted in part at Temple University School of Medicine (to W. J. K.) supported by National Institutes of Health Grants R37 HL061690, P01 HL075443 (Project 2), P01 HL108806 (Project 3) and P01 HL091799. This work was also supported by American Heart Association Grant N014938 (to K T. H.). The authors declare that they have no conflicts of interest with the contents of this article.
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© 2015 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.