Journal of Biological Chemistry
ENZYME CATALYSIS AND REGULATIONAspartate 313 in the Streptomyces plicatusHexosaminidase Plays a Critical Role in Substrate-assisted Catalysis by Orienting the 2-Acetamido Group and Stabilizing the Transition State*
Cited by (0)
Published, JBC Papers in Press, August 8, 2002, DOI 10.1074/jbc.M206481200
- *
This work was supported in part by the Medical Research Council of Canada; the Protein Engineering Network of Centres of Excellence of Canada, and the Natural Sciences and Engineering Research Council of Canada.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
The atomic coordinates and the structure factors (code 1M01,1M03 and 1M04) have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick, NJ (http://www.rcsb.org/).
- §
Supported by a postdoctoral fellowship from the Killam Trust, Canada. Present address: School of Chemistry, The University of Melbourne, Parkville, Vic 3052, Australia.
- ¶
These three authors contributed equally to this work.
- **
Supported by studentships from the Canadian Institutes for Health Research, the Alberta Heritage Foundation for Medical Research, and the University of Alberta.
- ‡
Supported by studentships from the British Columbia Science Council and the Natural Sciences and Engineering Research Council of Canada. Present address: Depts. of Chemistry and Molecular and Cell Biology, University of California, Berkeley, CA 94720.