Journal of Biological Chemistry
Volume 293, Issue 23, 8 June 2018, Pages 8874-8885
Signal TransductionAMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
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AMP-activated kinase (AMPK)
cell metabolism
drug development
inhibition mechanism
signaling
structure-function
appetite suppression
neuroprotection
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This work was supported by grants from the Australian Research Council (ARC), Cancer Australia, the National Health and Medical Research Council (NHMRC), and the Jack Brockhoff foundation (Grant JBF-4206, 2016). The authors declare that they have no conflicts of interest with the contents of this article.
This article contains Table S1 and Figs. S1–S4.
The atomic coordinates and structure factors (code 6BX6) have been deposited in the Protein Data Bank (http://wwpdb.org/).
- 1
An NHMRC Early Career Research Fellow. Supported in part by the Victorian Government's Operational Infrastructure Support Program.
- 2
Supported by the Department of Health and Human Services acting through the Victorian Cancer Agency (MCRF16007).
- 3
An NHMRC Research Fellow.
© 2018 Dite et al.