Journal of Biological Chemistry
ImmunologyHuman DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding
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This work was supported by core funding from the Institute of Molecular and Cell Biology (IMCB) and Institute of Medical Biology (IMB) Strategic Positioning Fund (Biomedical Research Council (BMRC), A*STAR) (to B. R. and R. M. S.), Young Investigator Grant YIG 2015 (BMRC, A*STAR) (to B. R. and R. M. S.), National Medical Research Council MS-CETSA platform Grant MOHIAFCAT2/004/2015 (to B. R. and R. M. S.), National Medical Research Council Young Investigator Grant NMRC/OFYIRG/0046/2017 (to F. L. Z.), National Health and Medical Research Council Grants 1142354 and 1099262 (to S. L. M.), funds from the Sylvia and Charles Viertel Foundation (to S. L. M.), a Howard Hughes Medical Institute–Wellcome International Research Scholarship (to S. L. M.), and funds from GlaxoSmithKline (to S. L. M.). The authors declare that they have no conflicts of interest with the contents of this article.
This article contains Videos S1–S3, Figs. S1–S4, and Excel Files S1 and S2.
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The abbreviations used are:
- PYD
pyrin domain
- IL
interleukin
- AIADK
autoinflammation with arthritis and dyskeratosis
- a.a.
amino acid(s)
- IP
immunoprecipitation
- MSPC
multiple self-healing palmoplantar carcinoma
- DKO
double-knockout
- PBMC
peripheral blood mononuclear cells
- FBS
fetal bovine serum
- TRITC
tetramethylrhodamine isothiocyanate
- ANOVA
analysis of variance
- OMIM
Online Mendelian Inheritance in Man
- PI
propidium iodide.