Journal of Biological Chemistry
Research ArticleEditors' PickHyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase
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Dr Harry C. Tjondro recently completed his PhD in Molecular Sciences from Macquarie University, Sydney, Australia. His research focuses on performing deep structural characterization of key neutrophil glycoproteins including myeloperoxidase using glycomics, glycopeptide, and glycoprotein-based mass spectrometry to decode how the unusual neutrophil glycosylation impacts neutrophil function in health and relevant diseases such as cystic fibrosis and sepsis. He can be found at Analytical Glycoimmunology Group, @HarryTjondro (Twitter).
Julian Ugonotti is a first-year PhD candidate, Department of Molecular Sciences, Macquarie University, Sydney, Australia. His research aims to utilize glycomics, glycoproteomics, and functional assays to investigate the immune-modulatory roles of protein paucimannosylation on key neutrophil glycoproteins, such as myeloperoxidase, and more broadly throughout the human innate immune system. He can be found at Analytical Glycoimmunology Group, @JUgonotti (Twitter).
Dr Rebeca Kawahara is an Early Career Fellow—Cancer Institute NSW, Department of Molecular Sciences, Macquarie University, Sydney, Australia. Her current focus is to understand how protein N-glycosylation modulates the tumor microenvironment and impacts the immune- and cancer-related anti- and proinflammatory processes in colorectal cancer. She can be found at Analytical Glycoimmunology Group and http://publicationslist.org/rebeca.kawahara.
Sayantani Chatterjee is a final-year PhD candidate, Department of Molecular Sciences, Macquarie University, Sydney, Australia. Her research focuses on performing structural characterization of mannose-containing glycoproteins from lysosomes and granular neutrophils in healthy and diseased states using glycomics and glycoproteomics to decode the extracellular roles of this modification in inflammation and cancer. She can be found at Analytical Glycoimmunology Group, @csayantani9 (Twitter).
This article contains supporting information.
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These authors contributed equally to this work.