Journal of Biological Chemistry
Volume 296, January–June 2021, 100127
Research ArticleEditors' PickThe cryo-EM structure of the endocytic receptor DEC-205
Editors' Pick
Under a Creative Commons license
open access
Keywords
immunology
cryo-electron microscopy
receptor structure function
oligomerization
membrane protein
receptor endocytosis
dendritic cell
Abbreviations
CpG
cytosine–guanosine
CTLDs
C-type lectin-like domains
CysR
cysteine-rich
DCs
dendritic cells
ECDs
ectodomains
eGFP
enhanced green fluorescent protein
FNII
fibronectin type II
MR
mannose receptor
PLA2R
M-type phospholipase A2 receptor
SEC-MALS
size exclusion–coupled multiangle light scattering
SV-AUC
sedimentation velocity analytical ultracentrifugation
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Benjamin Gully is a postdoctoral researcher and team leader within the Rossjohn Laboratory at the Monash Biomedicine Discovery Institute. His research investigates the paradigms of immune cell activation, including dendritic cells and gamma delta T-cells. By understanding these molecular events they are building a clearer picture of their functional roles in disease. Here they elucidated the structure of a dendritic cell receptor implicated in antigen uptake, a key step for T-cell surveillance. For more information please see @benjaminsgully twitter and https://research.monash.edu/en/persons/ben-gully.
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© 2020 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.