Journal of Biological Chemistry
JBC ReviewsA structural view of PA2G4 isoforms with opposing functions in cancer
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Funding and additional information—This work was supported by National Health and Medical Research Council (NHMRC) Australia Project Grant GNT1125171, an SVI Top-up scholarship (to B. W. S.), an NHMRC Senior Principal Research Fellowship (to M. W. P.), a 5-Point Foundation Postdoctoral Fellowship (to J. K. H.), NHMRC Program Grant GNT1016699 (to G. M. M.), Cancer Institute NSW Program Grant 10/TPG/1-13 (to G. M. M.), Cancer Council NSW Program Grant PG-11-06 (to G. M. M.), and Neuroblastoma Australia (to G. M. M. and B. B. C.).
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Abbreviations—The abbreviations used are:
- aa
amino acids
- PDB
Protein Data Bank
- RMSD
root mean square deviation
- MAP
methionine aminopeptidase
- eIF2α
eukaryotic initiation factor 2α
- IRES
internal ribosome entry site
- ITAF
IRES-trans-acting factor
- AR
androgen receptor
- PI3K
phosphatidylinositol 3-kinase
- Rb
retinoblastoma
- PSA
prostate-specific antigen
- MAPK
mitogen-activated protein kinase.