Journal of Biological Chemistry
Volume 294, Issue 11, 15 March 2019, Pages 3853-3871
Molecular Bases of DiseaseSpecies-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutationsGBA2 mutations and locomotor dysfunction
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open access
glycerosphingolipid
ataxia
neuroscience
neurite outgrowth
cytoskeleton
actin cytoskeleton
β-glucosidases
cerebellar ataxia
GBA2
glucosylceramide
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This work was supported by Deutsche Forschungsgemeinschaft (DFG) Grants SFB645 (to D. W. and P. D.), TRR83 (to D. W.), SPP1926 (to D. W.), SPP1726 (to D. W.), and FOR2743 (to D. W.), the Fritz-Thyssen Foundation (to D. W.), and the Boehringer Ingelheim Stiftung (to D. W.). The authors declare that they have no conflicts of interest with the contents of this article.
This article contains Figs. S1–S6 and Table S1.
- 1
Both authors contributed equally to this work.
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Present address: Institute of Pharmaceutical Microbiology, University of Bonn, 53115 Bonn, Germany.
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Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy – EXC2151 – 390873048.
© 2019 Woeste et al.