Journal of Biological Chemistry
MetabolismDipeptidyl peptidase 3 modulates the renin–angiotensin system in mice
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Author contributions—S. J., U. T., T. M., K. G., R. Z., and P. M. conceptualization; S. J., U. T., B. B., T. M., R. Z., and P. M. data curation; S. J., U. T., O. D., M. Poglitsch, B. B., M. Pollheimer, L. M. P., G. M., S. F., T. M., R. Z., and P. M. formal analysis; S. J., U. T., R. Z., and P. M. validation; S. J., U. T., O. D., M. Poglitsch, B. B., M. Pollheimer, L. M. P., G. M., S. F., T. M., K. G., R. Z., and P. M. investigation; S. J., U. T., M. Pollheimer, and P. M. visualization; S. J., U. T., O. D., M. Poglitsch, B. B., M. Pollheimer, S. F., T. M., K. G., R. Z., and P. M. methodology; S. J. and P. M. writing-original draft; S. J., U. T., R. Z., and P. M. writing-review and editing; U. T., R. Z., and P. M. supervision; K. G., R. Z., and P. M. resources; K. G. and P. M. funding acquisition; R. Z. and P. M. project administration; P. M. software.
Funding and additional information—This work was supported by Austrian Science Foundation Grant W901 (Doctoral Program “Molecular Enzymology”; to K. G., R. Z., and P. M.) and by the Interuniversity Program in Natural Sciences (to NAWI Graz).
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Abbreviations—The abbreviations used are:
- DPP3
dipeptidyl peptidase 3
- DPP3+/+
DPP3 wild-type
- DPP3−/−
DPP3-knockout
- RAS
renin–angiotensin system
- Ang
angiotensin
- ROS
reactive oxygen species
- ITC
isothermal titration calorimetry
- ACE
angiotensin-converting enzyme
- ARE
antioxidant response element
- CMV
cytomegalovirus
- EE
energy expenditure
- H2DCFDA
2′,7′-dichlorodihydrofluorescein diacetate
- E2
17β-estradiol.
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These authors contributed equally to this work.