Journal of Biological Chemistry
Volume 296, January–June 2021, 100150
Research ArticleAn inducible glycogen synthase-1 knockout halts but does not reverse Lafora disease progression in mice
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open access
Keywords
Lafora disease (Lafora progressive myoclonic epilepsy, MELF)
glycogen
glycogen synthase
glycogen storage disease
neuroinflammation
neurodegenerative disease
Lafora bodies
Abbreviations
CAL
corpora amylacea–like
GFAP
glial fibrillary acidic protein
GYS1
glycogen synthase-1
IBA1
ionized calcium–binding adapter molecule 1
LB
Lafora body
LD
Lafora disease
PASD
periodic acid–Schiff–diastase
TAM
tamoxifen
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These authors contributed equally to this work.
© 2020 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.