Molecular & Cellular Proteomics
Volume 18, Supplement 1, 15 March 2019, Pages S91-S108
ResearchProteomic Profiling of Mouse Epididymosomes Reveals their Contributions to Post-testicular Sperm Maturation
Under a Creative Commons license
open access
Graphical Abstract
Highlights
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Comparative proteomics of extracellular vesicles isolated from the mouse epididymis.
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Epididymosome proteome displays pronounced segment-to-segment variation.
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Epididymosomes deliver protein cargo to the sperm head.
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Mechanistic insights into role of epididymosomes in sperm maturation and storage.
Exosomes
Quantification
2-D Gel Electrophoresis
Cell biology*
Developmental biology*
Mass Spectrometry
Mouse models
epididymis
epididymosome
sperm
Cited by (0)
Author contributions: B.N., G.N.D.I., M.R.L., and M.D.D. designed research; B.N., G.N.D.I., H.M.H., W.Z., A.M., I.B., A.L.A., S.J.S., J.G.A., E.G.B., M.R.L., and M.D.D. analyzed data; B.N., M.R.L., and M.D.D. wrote the paper; H.M.H., W.Z., A.M., I.B., A.L.A., S.J.S., D.A.S.-B., M.F.B.J., J.G.A., E.G.B., M.R.L., and M.D.D. performed research.
This article contains supplemental material.
© 2019 Nixon et al.