Molecular & Cellular Proteomics
Volume 18, Issue 8, Supplement 1, 9 August 2019, Pages S26-S36
ResearchAn Integrative Analysis of Tumor Proteomic and Phosphoproteomic Profiles to Examine the Relationships Between Kinase Activity and Phosphorylation*
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open access
Graphical Abstract
Highlights
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Integration of proteomics and phosphoproteomics data to understand kinase activity.
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The abundance of some kinases correlates with activity.
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Kinase activity does not necessarily reflect phosphorylation of regulatory sites.
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Correlation patterns can be used to extend kinase substrate repertoire.
Ovarian cancer
Breast cancer
Cancer Biology
Computational Biology
iTRAQ
Phosphoproteome
Phosphorylation
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Author contributions: O.A.A., V.D., V.A.P., and J.E.M. analyzed data; O.A.A., K.R., and J.E.M. wrote the paper; P.D.P., T.L., K.D.R., and J.E.M. designed research.
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This work was supported by the National Cancer Institute Clinical Proteomic Tumor Analysis Consortium under grants U01CA214116 and U24CA210955.
This article contains supplemental Figures and Tables.
© 2019 Arshad et al.