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The absorption of α-tocopherol in man

Published online by Cambridge University Press:  09 March 2007

J. Kelleher  and
M. S. Losowsky
J. Kelleher
Affiliation:
Department of Medicine, University of Leeds, The General Infirmary, Leeds LSI 3 EX
M. S. Losowsky
Affiliation:
Department of Medicine, University of Leeds, The General Infirmary, Leeds LSI 3 EX
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Abstract

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1. Physiological oral doses of DL [5-Me-3H]α-tocopherol were administered to fasting subjects with various disease states, with and without steatorrhoea, and net absorption was calculated by measurement of faecal unabsorbed radioactivity. In each subject studied more than 70% of the faecal radioactivity was excreted as unchanged α-tocopherol.

2. α-Tocopherol absorption was significantly less in subjects with steatorrhoea (mean 59.4%, range 31–83%) than in those without steatorrhoea (mean 72.4%, range 51–86%). Nineteen out of twenty-four subjects with steatorrhoea absorbed less than 65% of the α-tocopherol dose, while twenty-two out of twenty-six subjects without steatorrhoea absorbed more than 65%. There was a significant correlation between the severity of steatorrhoea and α-tocopherol absorption. In a wide range of diseases steatorrhoea appeared to be the common factor associated with a decrease in α-tocopherol absorption; however, in subjects after gastric surgery α-tocopherol absorption was often low even in the absence of steatorrhoea, and this may be an important factor in explaining the high incidence of vitamin E deficiency in such patients.

3. Radioactivity in the plasma was maximal 6–12 h after dosing. Plasma radioactivity curves were significantly lower in patients with steatorrhoea than in those without steatorrhoea, but there was considerable overlap. In some patients with severe deficiency and severe steatorrhoea there was no detectable plasma response even with considerable absorption of up to 40% of the administered dose. Three patients with severe dietary deficiency of the vitamin and no steatorrhoea also showed a decreased plasma radioactivity.

4. Three subjects were studied twice, initially when deficient in α-tocopherol and a second time after repletion with α-tocopherol acetate. There was no evidence for a compensatory mechanism to increase α-tocopherol absorption in α-tocopherol deficiency.

5. A small quantity of the administered dose (almost always less than 6%) was excreted in the urine.

Type
Research Article
Information
British Journal of Nutrition , Volume 24 , Issue 4 , December 1970 , pp. 1033 - 1047
Copyright
Copyright © The Nutrition Society 1970

References

REFERENCES

Avioli, L. V. (1969). Am. J. clin. Nutr. 22, 437.CrossRefGoogle Scholar
Barker, H. G., Malm, J. H. & Roemtsma, K. (1960). N. Y. St. J. Med. 60, 1783.Google Scholar
Bieri, J. G. & Prival, E. L. (1965). Proc. Soc. exp. Biol. Med. 120, 554.CrossRefGoogle Scholar
Binder, H. J., Herting, D. L., Hurst, V., Finch, S. C. & Spiro, H. M. (1965). New Engl. J. Med. 273, 1289.CrossRefGoogle Scholar
Blomstrand, R. & Forsgren, L. (1968 a). Int. Z. VitaminForsch. 38, 328.Google Scholar
Blomstrand, R. & Forsgren, L. (1968 b). Int. Z. VitaminForsch. 38, 45.Google Scholar
Blomstrand, R. & Werner, B. (1967). Scand. J. clin. Lab. Invest. 19, 339.CrossRefGoogle Scholar
Bothwell, T. H. (1968). Br. J. Haemat. 14, 453.CrossRefGoogle Scholar
Bray, G. A. (1960). Analyt. Biochem. 1, 279.CrossRefGoogle Scholar
Brinkhous, K. M. & Warner, E. D. (1941). Am. J. Path. 17, 81.Google Scholar
Darby, W. J., Ferguson, M. E., Furman, R. H., Lemley, J. M., Ball, C. T. & Meneely, G. R. (1949). Ann. N. Y. Acad. Sci. 52, 328.CrossRefGoogle Scholar
Davies, T., Kelleher, J. & Losowsky, M. S. (1969). Clinica chim. Acta 24, 431.CrossRefGoogle Scholar
Desai, I. D., Parekh, C. K. & Scott, M. L. (1965). Biochim. biophys. Acta 100, 280.CrossRefGoogle Scholar
Diplock, A. T., Edwin, E. E., Bunyan, J. & Green, J. (1961). Br. J. Nutr. 15, 425.CrossRefGoogle Scholar
Dodge, J. T., Cohen, G., Kayden, H. J. & Phillips, G. B. (1967). J. clin. Invest. 46, 357.CrossRefGoogle Scholar
Dyer, N. H. & Dawson, A. M. (1968). Br. med. J. ii, 225.CrossRefGoogle Scholar
Edwin, E. E., Diplock, A. T., Bunyan, J. & Green, J. (1960). Biochem. J. 75, 450.CrossRefGoogle Scholar
Emmerie, A. & Engel, C. (1939). Recl. Trav. chim. Pays-Bas Belg. 57, 1351.CrossRefGoogle Scholar
Filer, L. J., Wright, S. W., Manning, M. P. & Mason, K. E. (1951). Paediatrics, Cairo 8, 328.Google Scholar
Folch, J., Lees, M. & Stanley, G. H. S. (1957). J. biol. Chem. 226, 497.CrossRefGoogle Scholar
Frazer, A. C. (1960). Association of Clinical Pathologists: Broadsheet no. 28.Google Scholar
Ganguly, J., Krishnamurthy, S. & Mahadevan, S. (1959 b) Biochem. J. 71, 756.CrossRefGoogle Scholar
Goodman, D. S., Blomstrand, R., Werner, B., Huang, H. S. & Shiratori, T. (1966). J. clin. Invest. 45, 1615.CrossRefGoogle Scholar
Gounelle, H., Marnay, C. & Blondin, M. (1953). C. R. Séanc. Soc. Biol. 147, 1598.Google Scholar
Greaves, J. D. & Schmidt, C. L. A. (1937). Proc. Soc. exp. Biol. Med. 37, 40.CrossRefGoogle Scholar
Harris, P. L. (1960). Vitams Horm. 18, 341.CrossRefGoogle Scholar
Hashim, S. A. & Schuttringer, G. R. (1966). Am. J. clin. Nutr. 19, 137.CrossRefGoogle Scholar
Hofmann, A. F. & Borgströom, B. (1962). Fedn Proc. Fedn Am. Socs. exp. Biol. 21, 43.Google Scholar
Hofmann, A. F. & Borgström, B. (1964). J. clin. Invest. 43, 247.CrossRefGoogle Scholar
Johnson, P. & Pover, N. F. R. (1962). Life Sci., N.Y. no. 4, p. 115.CrossRefGoogle Scholar
Kayden, H. J., Senior, J. R. & Mattson, F. H. (1967). J. clin. Invest. 46, 1695.CrossRefGoogle Scholar
Kayden, H. J. & Silber, R. (1965). Trans. Ass. Am. Physns 78, 334.Google Scholar
Kelleher, J., Davies, T. & Losowsky, M. S. (1969). Biochem. J. 114, 74 P.CrossRefGoogle Scholar
Klatskin, G. (1954). Ann. N.Y. Acad. Sci. 57, 909.CrossRefGoogle Scholar
Klatskin, G. & Krehl, W. A. (1950). J. clin. Invest. 29, 1528.CrossRefGoogle Scholar
Klatskin, G. & Molander, D. W. (1952). J. clin. Invest. 31, 159.CrossRefGoogle Scholar
Klatskin, G. & Tisdale, W. A. (1957). J. clin. Invest. 36, 1627.CrossRefGoogle Scholar
Krishnamurthy, S. & Bieri, J. G. (1963). J. Lipid Res. 4, 330.CrossRefGoogle Scholar
Lloyd, J. K. (1969). Am. clin. Biochem. 6, 46.CrossRefGoogle Scholar
Losowsky, M. S. & Leonard, P. J. (1967). Gut 8, 539.CrossRefGoogle Scholar
Losowsky, M. S., Leonard, P. J., Kelleher, J. & Pulvertaft, C. N. (1967). Am. J. clin. Nut. 20, 366.Google Scholar
Lundh, G. (1962). Gastroenterology 4, 637.CrossRefGoogle Scholar
McCormick, E. C., Cornwell, D. G. & Brown, J. B. (1960). J. Lipid Res. 1, 221.CrossRefGoogle Scholar
Mellors, A. & Barnes, M. McC. (1966). Br. J. Nutr. 20, 69.CrossRefGoogle Scholar
Muller, D. P. R. & Harries, J. T. (1969). Biochem. J. 112, 28P.Google Scholar
Pelkonen, R. (1963). Acta med. scand. Suppl. 399, 11.Google Scholar
Pomeranze, J. & Lucarello, R. J. (1953). J. Lab. clin. Med. 42, 700.Google Scholar
Rose, G. A. (1964). Gut 5, 274.CrossRefGoogle Scholar
Rosenkrantz, H., Milhorat, A. T. & Farber, M. (1953). Metabolism 2, 556.Google Scholar
Schmandke, H. (1967). Wiss. Veröff. dt. Ges. Ernahr. 16, 80.Google Scholar
Schmandke, H. & Proll, J. (1964). Int. Z. VitaminForsch. 34, 312.Google Scholar
Senior, J. R. (1964). J. Lipid Res. 5, 495.CrossRefGoogle Scholar
Simon, E. J., Gross, C. S. & Milhorat, A. T. (1956). J. biol. Chem. 221, 797.CrossRefGoogle Scholar
Skinner, W. A., Parkhurst, R. M. & Alaupovic, P. (1964). J. Chromat. 13, 240.CrossRefGoogle Scholar
Society for Analytical Chemistry: Analytical Methods Committee (1959). Analyst, Lond. 84, 356.CrossRefGoogle Scholar
Sternberg, J. & Pascoe-Dawson, E. (1959). Can. med. Ass. J. 80, 266.Google Scholar
Stowe, H. D. (1963). Archs Biochem. Biophys. 103, 42.CrossRefGoogle Scholar
Tendille, C., Bats, J., Gervais, C. & Gaborit, T. (1965). Annls Physiol. veg., Paris. 7, 85.Google Scholar
Thompson, G. R., Lewis, B. & Booth, C. C. (1966). J. clin. Invest. 45, 94.CrossRefGoogle Scholar
van de Kamer, J. H., Huinink, H. T. B. & Weyers, H. A. (1949). J. bid. Chem. 177, 347.CrossRefGoogle Scholar
Ways, P. O., Parmentier, C. M., Kayden, H. J., Jones, J. W., Saunders, D. R. & Rubin, C. E. (1967). J. clin. Invest. 46, 35.CrossRefGoogle Scholar
Week, E. F., Sevigne, F. J. & Ellis, M. E. (1952). J. Nutr. 46, 353.CrossRefGoogle Scholar
Wiss, O., Bunnell, R. H. & Gloor, U. (1964). Vitams Horm. 20, 441.CrossRefGoogle Scholar