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A study of the thermic responses to a meal and to a sympathomimetic drug (ephedrine) in relation to energy balance in man

Published online by Cambridge University Press:  24 July 2007

Jane B. Morgan ,
David A. York ,
Amanda Wasilewska  and
Jan Portman
Jane B. Morgan
Affiliation:
Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton, Southampton SO9 5NH
David A. York
Affiliation:
Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton, Southampton SO9 5NH
Amanda Wasilewska
Affiliation:
Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton, Southampton SO9 5NH
Jan Portman
Affiliation:
Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton, Southampton SO9 5NH
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Abstract

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1. Sixteen adult male volunteers were selected on the basis of body size and customary food intake: half could be described as‘lean’and habitually consuming large amounts of food (group mean ± SEM: 15·03± 1·13 MJ/d), the high-energy-intake group (HEI group), and half though‘lean’admitted to a weight problem and regularly consumed a lower than average food intake (group mean ± SEM: 6·90 ± 0·39 MJ/d), the low-energy-intake group (LEI group).

2. Energy expenditure was measured by open-circuit indirect calorimetry. Resting metabolic rate (RMR) was recorded. A meal (Complan, either 2·1 MJ or 4·2 MJ), ephedrine hydrochloride (0·25 mg and 0·50 mg/kg body-weight) or a water control were then administered and metabolic rate (MR) was measured for 4 h. Blood was collected before and 1 h after the meal or drug, and the serum analysed for various hormones and blood metabolites.

3. The size of the thermic response to feeding but not the time-course was related to meal size in both groups. MR increased by 21·6 and 28·6% in the HEI group and by 8·2 and 20·0% in the LEI group in response to the 2·1 and 4·2 MJ Complan meals respectively. Fasting insulin levels were similar in both groups but showed a significantly higher level in the LEI than HEI group after the Complan meals.

4. The mean RMR increased by 5·2 and 10·3% in the LEI in response to ephedrine and by 15·7 and 11·2% in the HEI groups after 0·25 mg and 0·50 mg ephedrine/kg respectively. The rise in serum-free fatty acids in response to ephedrine was significantly higher in the HEI group than in the LEI group.

5. These results suggest (1) the meal size required to promote a maximum thermic effect is smaller in energetically inefficient individuals (2) the sensitivity to a sympathomimetic drug is also increased in energetically-inefficient individuals.

6. We conclude that in energetically-efficient individuals both the thermic response to a meal and the sympathetic-mediated thermogenesis are lower than in energetically-inefficient ones.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 47 , Issue 1 , January 1982 , pp. 21 - 32
Copyright
Copyright © The Nutrition Society 1982

References

Apfelbaum, M. (Ed.) (1973). Energy Balance in Man. Paris: Masson et cie.Google Scholar
Bray, G. A. (1970). Am. J. clin. Nutr. 23, 1141.CrossRefGoogle Scholar
Bray, G. A., Whipp, B. & Koyal, S. N. (1973). Am. J. clin. Nutr. 27, 254.CrossRefGoogle Scholar
Carruthers, M. & Young, D. A. B. (1973). Clinica chim. Acta 49, 341.CrossRefGoogle Scholar
Cawthorne, M. A. & Arch, J. R. S. (1980). Aliment. Nutr. Metab. 1, 240.Google Scholar
Danforth, E., Horton, E., O'Connell, M., Sims, E., Burger, A., Ingbar, S., Brurerman, L. & Vagendeis, A. J. (1979). J. clin. Invest. 64, 1336.CrossRefGoogle Scholar
Dauncy, J. (1980). Br. J. Nutr. 43, 257.CrossRefGoogle Scholar
De Jong, F. H. & van der Molen, H. J. (1972). J. Endocr. 53, 461.CrossRefGoogle Scholar
Durnin, J. V. G. A. & Womersley, J. (1974). Br. J. Nutr. 32, 77.CrossRefGoogle Scholar
Fabry, P., Fodor, J., Heijl, Z., Braun, P. & Zvolankova, K. (1964). Lancet ii, 614.CrossRefGoogle Scholar
Garrow, J. S. (1974). Energy Balance and Obesity in Man. Amsterdam, New York and Oxford: Elsevier/North Holland Biomedical Press.Google Scholar
Garrow, J. S. (1978). Recent Advances in Obesity Research, vol. 2 Proceedings of the 2nd International Congress on Obesity [Bray, G. A., editor]. London: Newman Publishing Ltd.Google Scholar
Garrow, J. S., Blaze, S. E., Warwick, P. M. & Ashwell, M. A. (1980). Lancet i. 1103.CrossRefGoogle Scholar
Godbole, V. & York, D. A. (1978). Diabetologia 14, 191.CrossRefGoogle Scholar
Goldman, R. F., Hausman, M. F., Bynum, G., Horton, E. S. & Sims, E. A. H. (1976). Obesity in Perspective [Bray, G. A., editor]. Washington, DC: US Government Printing Office.Google Scholar
Himms-Hagen, J. (1976). A. Rev. Physiol. 38, 315.CrossRefGoogle Scholar
Jung, R., Shetty, P. & James, W. P. T. (1979). Nature, New Biol. 279, 322.CrossRefGoogle Scholar
Kaplan, M. L. & Leveille, G. A. (1976). Am. J. clin. Nutr. 29, 1108.CrossRefGoogle Scholar
Miller, D. S. (1976). Obesity in Perspective [Bray, G. A., editor]. Washington, DC: US Government Printing Office.Google Scholar
Miller, D. S., Mumford, P. M. & Stock, M. J. (1967). Am. J. clin. Nutr. 20, 1223.CrossRefGoogle Scholar
Passmore, R. & Durnin, J. V. G. A. (1955). Physiol. Rev. 35, 801.CrossRefGoogle Scholar
Paul, A. A. & Southgate, D. A. T. (1978). Med. Res. Coun. Spec. Rep. Ser. no. 297.Google Scholar
Pittet, Ph., Chappuis, Ph., Acheson, K., De Techtermann, F. & Jéquier, E. (1976). Br. J. Nutr. 35, 281.CrossRefGoogle Scholar
Rabinowitz, D. (1970). A. Rev. Med. 21, 241.CrossRefGoogle Scholar
Rose, G. A. & Williams, R. T. (1961). Br. J. Nutr. 15, 1.CrossRefGoogle Scholar
Rossini, A., Goldman, R. F. & Cahill, G. F. Jr (1977). Metabolism 26, 637.CrossRefGoogle Scholar
Rothwell, N. J. & Stock, M. J. (1979). Nature, New Biol 281, 31.CrossRefGoogle Scholar
Rush, R. L., Leon, L. & Turrell, J. (1970). Adv. Automated Analysis 1, 503.Google Scholar
Sims, E. A. H., Danforth, E., Horton, E., Bray, G. A., Glennon, J. & Salams, L. (1973). Rec. Prog. Horm. Res. 29, 457.Google Scholar
Stirling, J. L. & Stock, M. J. (1968). Nature, Lond. 220, 801.CrossRefGoogle Scholar
Stordy, B., Marks, V., Kalucy, R. & Crisp, A. (1977). Am. J. clin. Nutr. 30, 138.CrossRefGoogle Scholar
Trinders, T. (1976). Technicon clinical methods no. 507–72E. Tarrytown, New York: Technicon Instruments Co. Ltd.Google Scholar
Webb, P. (1980). Am. J. clin. Nutr. 33, 1299.CrossRefGoogle Scholar
Widdowson, E. M. (1947). Spec. Rep. Ser. Med. Res. Coun. no. 257.Google Scholar