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Hymenolepis microstoma: direct life cycle in immunodeficient mice

Published online by Cambridge University Press:  12 April 2024

J. Andreassen ,
A. Ito ,
M. Ito ,
M. Nakao  and
K. Nakaya
J. Andreassen
Affiliation:
Department of Parasitology, Midorigaoka-Higashi 2-1-1-1, Asahikawa, 078-8510, Japan, :
A. Ito*
Affiliation:
Animal Laboratory for Medical Research, Asahikawa Medical College, Midorigaoka-Higashi 2-1-1-1, Asahikawa, 078-8510, Japan, :
M. Ito
Affiliation:
Central Institute for Experimental Animals, Miyamae, Kawasaki, 216-0001, Japan
M. Nakao
Affiliation:
Animal Laboratory for Medical Research, Asahikawa Medical College, Midorigaoka-Higashi 2-1-1-1, Asahikawa, 078-8510, Japan, :
K. Nakaya
Affiliation:
Animal Laboratory for Medical Research, Asahikawa Medical College, Midorigaoka-Higashi 2-1-1-1, Asahikawa 078-8510, Japan.
*
*Author for correspondenceFax: +81-166-68-2429 Email: akiraito@asahikawa-med.ac.jp
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Abstract

The mouse bile duct tapeworm Hymenolepis microstoma requires beetles as the obligatory intermediate host. However, when congenitally athymic NMRI-nu mice were infected with the mature tapeworm and allowed to eat their own faeces with tapeworm eggs, the oncospheres penetrated the intestinal tissue and developed to cysticercoids. After excysting, growth to adult worms occurs in the lumen of the small intestine and bile duct. Furthermore, the same happened when NMRI-nu mice, non-obese diabetic severe combined immunodeficiency (NOD/Shi-scid) mice and NOD/Shi-scid, IL-2 Rγnull (NOG) mice were orally inoculated with shell-free eggs of this parasite. Differences between the cysticercoids of H. microstoma and H. nana developed in the mouse intestinal tissues were: (i) the time course for the development of fully matured cysticercoids of H. microstoma in mice was about 11 days but only 4 days for H. nana; and (ii) cysticercoids of H. microstoma developed in mice had a tail while those of H. nana had none.

Type
Review Article
Information
Journal of Helminthology , Volume 78 , Issue 1 , March 2004 , pp. 1 - 5
Copyright
Copyright © Cambridge University Press 2004

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