Cytogenetics of lymphomas
References (141)
- et al.
A new method to extract nuclei from paraffin-embedded tissue to study lymphomas using interphase fluorescence in situ hybridization
Am J Pathol
(2002) - et al.
Spectral karyotyping identifies new rearrangements, translocations, and clinical associations in diffuse large B-cell lymphoma
Blood
(2002) - et al.
Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia
Cancer Genet Cytogenet
(2004) - et al.
Frequent aberrations of chromosome 8 in aggressive B-cell non-Hodgkin lymphoma
Cancer Genet Cytogenet
(2005) - et al.
The Burkitt-like lymphomas: a Southwest Oncology Group study delineating phenotypic, genotypic and clinical features
Blood
(2001) - et al.
The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile
Blood
(2002) - et al.
BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma
Blood
(1997) - et al.
BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma
Am J Pathol
(2004) - et al.
Rearrangements of bcl-6, bcl-2, c-myc and 6q deletion in B-diffuse large-cell lymphoma: clinical relevance in 71 patients
Ann Oncol
(1998) - et al.
Clinical relevance of BCL2, BCL6 and MYC rearrangements in diffuse large B-cell lymphoma
Blood
(1998)
Chromosomal and gene amplification in diffuse large B-cell lymphoma
Blood
Chromosomal translocations and their role in the pathogenesis of non-Hodgkins's lymphomas
Pathology
Variant t(14;18) in malignant lymphoma: a report of seven cases
Cancer Genet Cytogenet
Homozygous deletions at chromosome 9p21 involving p16 and p15 are associated with histologic progression in follicle center lymphoma
Blood
Follicular lymphoma with t(8;14)(q24;q32): a distinct clinical and molecular subset of t(8;14)- bearing lymphomas
Blood
Chromosomal analyses of 52 cases of follicular lymphoma with t(14;18), including blastic/blastoid variant
Cancer Genet Cytogenet
Cytomorphologic, immunohistochemical and cytogenetic profiles of follicular lymphoma: 2 types of follicular lymphoma grade 3
Blood
Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27 or other translocations: t(14;18) and 3q27 are mutually exclusive
Blood
t(14;19)/BCL3 rearrangements in lymphoproliferative disorders: a review of 23 cases
Cancer Genet Cytogenet
VH mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
Blood
Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors
Blood
Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features
Blood
T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma
Blood
BCL10 mutation does not represent an important pathogenic mechanism in gastric MALT-type lymphoma, and the presence of the AP12-MLT fusion is associated with aberrant nuclear BCL10 expression
Blood
Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways
Am J Pathol
t(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10
Blood
t(11;18) is a marker for all gastric MALT lymphomas that will not respond to H. pylori eradication
Gastroenterology
Gastric marginal zone B-cell lymphomas of MALT type develop along two distinct pathogenetic pathways
Blood
7q31-32 allelic loss is a frequent finding in splenic marginal zone lymphoma
Am J Pathol
Splenic marginal zone lymphoma: clinical characteristics and prognostic factors in a series of 60 patients
Blood
A comparative analysis of FISH, RT-PCR, PCR and immunohistochemistry for the diagnosis of mantle cell lymphomas
Mod Pathol
Molecular cytogenetic study of a mantle cell lymphoma with a complex translocation involving the CCND1 (11q13) region
Cancer Genet Cytogenet
Banded chromosomes versus fluorescence in situ hybridization in the diagnosis of mantle cell lymphoma: a lesson from three cases
Cancer Genet Cytogenet
Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features
Mod Pathol
Cytogenetic findings in blastoid mantle cell lymphoma
Hum Pathol
Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array- based comparative genomic hybridization
Blood
A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease
Blood
Indolent mantle cell lymphoma with nodal involvement and mutated immunoglobulin heavy chain genes
Hum Pathol
Chromosome changes in 19 patients with Waldenstrom's macroglobulinemia
Cancer Genet Cytogenet
t(9;14)(p13;q32) denotes a subset of low-grade non-Hodgkin lymphoma with plasmacytoid differentiation
Blood
Waldenstrom macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions
Blood
Lack of PAX5 rearrangements in lymphoplasmacytic lymphomas: reassessing the reported association with t(9;14)
Hum Pathol
Gain ofchromosome 3/3q in B-cell chronic lymphoproliferative disorder is associated with plasmacytoid differentiation with or without IgM overproduction
Cancer Genet Cytogenet
Proliferation and cytogenetic analysis of hairy cell leukemia upon stimulation via the CD40 antigen
Blood
Cytogenetic analysis of 147 cases of non-Hodgkin lymphoma: non-random chromosomal abnormalities and histological correlations
Br J Haematol
The lymphomas and chronic lymphoid leukaemias
The impact of the new FISH technologies on the cytogenetics of haematological malignancies
Br J Haematol
Improved technique for fluorescence in situ hybridization analysis of isolated nuclei from archival, B5 or formalin fixed, paraffin wax embedded tissue
J Clin Pathol
Karyotyping human chromosomes by combinatorial multi-fluorescence FISH
Nat Genet
Multicolor spectral karyotyping of human chromosomes
Science
Cited by (34)
BCL2, BCL6, IGH, TP53, and MYC protein expression and gene rearrangements as prognostic markers in diffuse large B-cell lymphoma: A study of 44 Turkish patients
2014, Cancer GeneticsCitation Excerpt :Cytogenetic analysis is now a routine part of the diagnosis and management of various types of NHL. Traditional cytogenetic studies as well as FISH analyses utilizing locus-specific DNA probes are used to identify specific genetic abnormalities that provide insight into the pathogenesis of this complex disease and to define distinct subgroups with variable prognoses (33). Cytogenetic and molecular cytogenetics in DLBCL showed that tumor cells carry nonrandom chromosomal aberrations, most frequently chromosomal translocations, deletions, or amplifications, as well as gene alterations, including somatic hypermutations (34).
Lessons we learn from hematopathology consultation in Taiwan
2013, Journal of the Formosan Medical AssociationCitation Excerpt :Anaplastic lymphoma kinase (ALK) detection may not be helpful because it is negative in some anaplastic large cell lymphomas and positive in some carcinomas, especially those of pulmonary origin.20,21 In the more complex cases, T-cell or B-cell clonality and specific genetic studies for genetic signatures may be useful.17,18,22 In addition, the importance of a patient's clinical history and communication between pathologists and oncologists cannot be overemphasized.
Nonmucosa-associated lymphoid tissue lymphomas of gastric and intestinal origin differ in their clinical features: A single institute experience
2011, Journal of the Chinese Medical AssociationCitation Excerpt :Fourthly, no significant prognostic factor of PFS was found; the assumed probable reason was inadequately analyzed parameters. Some other factors, such as pathological characteristics,23,24 cytogenetic abnormalities,25 beta-2 microglobulin26 and absolute lymphocyte count27 might also have had an impact on the outcomes. Finally, the number of patients receiving IFRT and autologous stem cell transplantation was extremely low.
Primary cardiac lymphoma: molecular cytogenetic characterization of a rare entity
2009, Cardiovascular PathologyCitation Excerpt :Gains of Chromosome 12 have been associated with transformation of follicular lymphoma to DLBCL [9–11]. Chromosomal translocations affecting band 3q27 and deletion of band 6q are common in DLBCL and have been associated with different clinical outcomes [10,12,13]. Relatively little is known about the cytogenetic alterations that may be associated with PCL.
Lymphoid Malignancies of Non-precursor Cells: General Considerations
2008, Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular ApproachesTelomere aggregates in non-Hodgkin lymphoma patients at different disease stages
2008, Cancer Genetics and CytogeneticsCitation Excerpt :It spans a broad age range and is heterogeneous in morphologic appearance, immunophenotype, and biologic behavior, including response to chemotherapy and ultimate outcome. Although DLBCL is potentially curable with conventional anthracycline-based chemotherapy, variability in response is often observed, further emphasizing the diversity of this disease [13–15]. The following genetic instability parameters were reported in non-Hodgkin lymphoma (NHL) leukocytes: short telomeres [2], centrosome abnormalities [16], and higher random aneuploidy rate and asynchronous replication at different disease stages (diagnosis, treatment, remission, and relapse) than those of the control group [17,18].