Abstract
The cerebellum has a uniform cellular structure and microcircuitry, but the size of its subdivisions varies greatly among vertebrates. This variability is a challenge to anatomists to attempt to relate size differences to differences in characteristic behaviour. Here we review the early work of Lodewijk Bolk on the mammalian cerebellum and relate his observations to unfolded maps of the rodent cerebella. We further take insights from the comparative anatomy of the bird cerebella and find that cerebellar enlargement in large brains is not a passive consequence of overall brain enlargement, but is related to specific behaviour. We speculate that for some rodents (e.g., squirrels), primates and some large-brained birds (crows, parrots and woodpeckers), specifically enlarged cerebella are associated with either the elaboration of forelimb control (squirrels and primates) or in the case of the birds with beak control. The elaboration of such motor behaviour combined with increased visual control could have helped to furnish manipulative skills in these animals. Finally, we review the connections of the mammalian cerebellum and show that several pieces of experimental evidence point to an important function of the cerebellum in sensory control of movement reflex adjustment, and motor learning.
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Ramón y Cajal, S. Histologie du système nerveux de l’homme et vertébrés. Vol. 2. Paris: Maloine; 1911.
Sultan F, Bower JM. Quantitative Golgi study of the rat cerebellar molecular layer interneurons using principal component analysis. J Comp Neurol. 1998;393:353–73.
Dieudonne S, Dumoulin A. Serotonin-driven long-range inhibitory connections in the cerebellar cortex. J Neurosci. 2000;20:1837–48.
Mugnaini E, Dino MR, Jaarsma D. The unipolar brush cells of the mammalian cerebellum and cochlear nucleus: cytology and microcircuitry. [Review], Progr Brain Res. 1997;114: 131–50.
Voogd J, Gerrits NM, Hess DT. Parasagittal zonation of the cerebellum in macaques: an analysis based on acetylcholinesterase histochemistry. In: Glickstein M, Yeo C, Stein J, editors. Cerebellum and neuronal plasticity. New York/ London: Plenum Press; 1987. pp 15–39.
Brochu G, Maler L, Hawkes R. Zebrin II: a polypeptide antigen expressed selectively by purkinje cells reveals compartments in rat and fish cerebellum. J Comp Neurol. 1990;291:538–52.
Wylie DR, Marzban H, Hawkes R, Iwaniuk AN, Pakan JP. Zebrin II expresion in the cerebellum of pigeons: stripes. Soc Neurosci. 2006;149:20.
Hawkes R, Eisenman LM. Stripes and zones: the origins of regionalization of the adult cerebellum. Perspect Dev Neurobiol. 1997;5:95–105.
Bolk L. Das cerebellum der Säugetiere. Jena: Fischer, G.; 1906.
Braitenberg V, Atwood RP. Morphological observations on the cerebellar cortex. J Comp Neurol. 1958;109:l-34.
Sultan F, Braitenberg V. Shapes and sizes of different mammalian cerebella. A study in quantitative comparative neuroanatomy. J Hirnforsch. 1993;34:79–92.
Nowak RM. Walker’s mammals of the world. 6th ed. Baltimore: Johns Hopkins University Press; 1999.
Van Hooser SD, Nelson SB. The squirrel as a rodent model of the human visual system. Vis Neurosci. 2006;23:765–78.
Stalheim-Smith A. Comparative study of the forelimbs of the semifossorial Prairie Dog,Cynomys gunnisoni, and the scansorial Fox Squirrel, Sciurus niger. J Morphol. 1984;180:55–68.
Stalheim-Smith A. Comparison of the muscle mechanics of the forelimb of three climbers. J Morphol. 1989;202: 89–98.
Brenowitz GL. Cutaneous mechanoreceptor distribution and its relationship to behavioral specializations in squirrels. Brain Behav Evol. 1980;17:432–53.
Brenowitz GL. Control of food handling by cutaneous receptor input in squirrels. Brain Behav Evol. 1980;17: 478–90.
Riley HA. The mammallian cerebellum. Arch Neurol Psychiatry. 1928;20:895–1034.
Leiner HC, Leiner AL, Dow RS. Does the cerebellum contribute to mental skills? Behav Neurosci. 1986;100: 443–54.
Paulin MG. The role of the cerebellum in motor control and perception. Brain Behav Evol. 1993;41:39–50.
Bower JM. Control of sensory data acquisition. [Review], Int Rev Neurobiol. 1997;41:489–513.
Sultan F. Why some bird brains are larger than others. Curr Biol. 2005;15:R649–50.
Larseil O. The development and subdivisions of the cerebellum of birds. J.Comp Neurol. 1948;89:123–89.
Larsell O, Whitlock DG. Further observations on the cerebellum of birds. J Comp Neurol. 1952;97:545–66.
Senglaub K. Das Kleinhirn der vögel in beziehung zu phylogenetischer Stellung, lebensweise und körpergrösse, nebst beiträgen zum domestikationsproblem. Zeitschrift Wissentschaft Zool. 1964;169:2–63.
Legg CR, Mercier B, Glickstein M. Corticopontine projection in the rat: the distribution of labelled cortical cells after large injections of horseradish peroxidase in the pontine nuclei. J Comp Neurol. 1989;286:427–41.
Glickstein M, May JG, III, Mercier BE. Corticopontine projection in the Macaque: the distribution of labelled cortical cells after large injections of horseradish peroxidase in the pontine nuclei. J Comp Neurol. 1985;235:343–59.
Miles FA, Fuller JH. Adaptive plasticity in the vestibuloocular responses of the Rhesus Monkey. Brain Res. 1974;80:512–6.
McCormick DA, Thompson RF. Cerebellum: essential involvement in the classically conditioned eyelid response. Science. 1984;223(4633):296–9.
Barash S, Melikyan A, Sivakov A, Zhang M, Glickstein M, Thier P. Saccadic dysmetria and adaptation after lesions of the cerebellar cortex. J Neurosci. 1999;19:10931–9.
Yeo CH, Hardiman MJ, Glickstein M. Discrete lesions of the cerebellar cortex abolish the classically conditioned nictitating membrane response of the rabbit. Behav Brain Res. 1984;13:261–6.
Mlikovsky J. Brain size in birds 4. Passeriformes. Acta Soc Zool Bohemoslov. 1992;54:27–37.
Mlikovsky J. Brain size in birds 2. Falconiformes through gaviiformes. Vestnik Ceskoslovens Spolec Zool. 1990;53: 200–13.
Mlikovsky J. Brain size in birds 3. Columbiformes through piciformes. Vestnik Ceskoslovens Spolec Zool. 1989;53: 252–64.
Mlikovsky J. Brain size in birds 1. Tinamiformes through ciconiformes. Vestnik Ceskoslovens Spolec Zool. 1989;53: 33–47.
Portmann A. Études sur la cérébralisation chez les oiseaux:II. Les indices intra-céré-braux. Alauda. 1947;15:1–15.
Portmann A. Études sur la cérébralisation chez les oiseaux:III.Cérébralisation et mode Ontogénétique. Alauda. 1947;15:161–71.
Portmann A. Études Sur La Cérébralisation Chez Les Oiseaux:I. Alauda. 1946;14:2–20.
Iwaniuk AN, Nelson JE. A comparative analysis of relative brain size in waterfowl (Anseriformes). Brain Behav Evol. 2001;57:87–97.
Rehkamper G, Schuchmann KL, Schleicher A, Zilles K. Encephalization in hummingbirds (Trochilidae). Brain Behav Evol. 1991;37:85–91.
Rehkamper G, Frahm HD, Zilles K. Quantitative development of brain and brain structures in birds (galliformes and passeriformes) compared to that in mammals (insectivores and primates). Brain Behav Evol. 1991;37:125–43.
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Sultan, F., Glickstein, M. The cerebellum: Comparative and animal studies. Cerebellum 6, 168–176 (2007). https://doi.org/10.1080/14734220701332486
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DOI: https://doi.org/10.1080/14734220701332486