Elsevier

Pathology

Volume 43, Issue 4, June 2011, Pages 295-301
Pathology

Optimising the management of soft tissue tumours

https://doi.org/10.1097/PAT.0b013e3283464427Get rights and content

Summary

The Royal College of Pathologists of Australasia is developing a series of protocols as an educational tool to assist pathologists in the reporting of relevant information for specific cancer specimens. The protocol for the management of soft tissue tumour resections has recently been released, and this document elaborates the relevant literature on which that protocol drew. Sarcoma is uncommon but is associated with significant morbidity and mortality, and its management is complex. Diagnostic errors are not uncommon and these can have disastrous effects on patient outcome. Sophisticated ancillary testing is often an important adjunct to diagnosis and prognostication. Referral to a specialist sarcoma unit is indicated for both adult and paediatric sarcoma.

References (70)

  • S. Edge et al.
  • D. Lum et al.

    Peritoneal metastases from an atypical fibroxanthoma

    Am J Surg Pathol

    (2006)
  • M. Miettinen

    Fibroblastic and myofibroblastic neoplasms with malignant potential.

  • K. Thway et al.

    Histopathological diagnostic discrepancies in soft tissue tumours referred to a specialist centre

  • G. Johnson et al.

    Delays in referral of soft tissue sarcomas

  • C. Stiller et al.

    Patterns of care and survival for patients aged under 40 years with bone sarcoma in Britain, 1980-1994

    BrJ Cancer

    (2006)
  • J. Abellan et al.

    Nonreferral of possible soft tissue sarcomas in adults: a dangerous omission in policy

  • J. Coindre

    Grading of soft tissue sarcomas: review and update

    Arch Pathol LabMed

    (2006)
  • J. Coindre et al.

    Prognostic factors in adult patients with locally controlled soft tissue sarcoma: a study of 546 patients from the French Federation of Cancer Centers Sarcoma Group

    J Clin Oncol

    (1996)
  • P. Pisters et al.

    Analysis of prognostic factors in 1041 patients with localized soft tissue sarcomas of the extremities

    J Clin Oncol

    (1996)
  • M. Eriksson

    Histology-driven chemotherapy of soft-tissue sarcoma

    Ann Oncol

    (2010)
  • K. Thornton

    Trabectedin: the evidence for its place in therapy in the treatment of soft tissue sarcoma

    Core Evid

    (2010)
  • R. Canter et al.

    Radiographic and histologic response to neoadjuvant radiotherapy in patients with soft tissue sarcoma

    Ann Surg Oncol

    (2010)
  • T. Donahue et al.

    Evaluation of neoadjuvant therapy and histopathologic response in primary, high-grade retroperitoneal sarco-mas using the sarcoma nomogram

    Cancer

    (2010)
  • M. Trojani et al.

    Soft-tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system

    Int J Cancer

    (1984)
  • M. Miettinen

    Overview of soft tissue tumors.

  • I. Hoeber et al.

    Accuracy of biopsy techniques for limb and limb girdle soft tissue tumors

    Ann Surg Oncol

    (2001)
  • D. Strauss et al.

    The role of core needle biopsy in the diagnosis of suspected soft tissue tumours

    J Surg Oncol

    (2010)
  • S. Weiss et al.
  • S. Weiss et al.
  • N. Kawaguchi et al.

    The concept of curative margin in surgery for bone and soft tissue sarcoma

    Clin Orthop

    (2004)
  • E. Novais et al.

    Do surgical margin and local recurrence influence survival in softtissue sarcomas?

    Clin Orthop Relat Res

    (2010)
  • View full text